Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Edetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | EYA2 | O00167 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Edetic Acid SCHEMBL10780643 | 0.97 | KDM4E (0.73) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL2945908 | 0.97 | KDM4E (0.65) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL9131150 | 0.97 | KDM4E (0.71) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL1938902 | 0.94 | KDM4E (0.68) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL7079696 | 0.94 | KDM4E (0.68) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL3103687 | 0.94 | KDM4E (0.68) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL6265241 | 0.94 | KDM4E (0.68) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL2115355 | 0.94 | KDM4E (0.68) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL906 | 0.94 | KDM4E (0.76) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL5315227 | 0.94 | KDM4E (0.68) | KDM4EALOX15MAPTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5449509-A | Desensitizing dentifrice | BEECHAM GROUP P.L.C. (GB) | 1995-09-12 | — | — | US | claimed |
| EP-0200323-B1 | ORAL HYGIENE COMPOSITION | BEECHAM GROUP PLC (GB) | 1992-05-20 | — | — | EP | claimed |
| EP-0080293-B1 | FLUORIDE CONTAINING DENTIFRICE | Schole, Murray L. (US) | 1987-04-15 | — | — | EP | claimed |
| EP-0080293-A2 | Fluoride containing dentifrice | Schole, Murray L. (US) | 1983-06-01 | — | — | EP | claimed |
| EP-0079611-A2 | Oral compositions containing strontium EDTA complex and soluble fluoride | Richardson-Vicks, Inc. (US) | 1983-05-25 | — | — | EP | claimed |
| US-4367219-A | STRONTIUM ETHYLENEDIAMINE TETRAACETATE | SCHOLE MURRAY L | 1983-01-04 | — | — | US | claimed |
| WO-2024258867-A1 | SYSTEM AND METHOD FOR PRESERVING ALGAE | Macro Oceans Inc. (US) | 2024-12-19 | — | — | WO | disclosed |
| US-20240409878-A1 | SYSTEM AND METHOD FOR PRESERVING ALGAE | Macro Oceans Inc. (US) | 2024-12-12 | — | — | US | disclosed |
| US-20230255857-A1 | DENTAL COMPOSITION CONTAINING ION SUSTAINED-RELEASE GLASS | SHOFU INC. (JP) | 2023-08-17 | — | — | US | disclosed |
| US-11648184-B2 | Dental composition containing ion sustained-release glass | SHOFU INC. (JP) | 2023-05-16 | — | — | US | disclosed |
| US-11559471-B2 | Dental composition containing ion sustained-release glass | SHOFU INC. (JP) | 2023-01-24 | — | — | US | disclosed |
| US-20220287944-A1 | SILK PERSONAL CARE COMPOSITIONS | EVOLVED BY NATURE INC (US) | 2022-09-15 | — | — | US | disclosed |
| EP-4017537-A1 | SILK PERSONAL CARE COMPOSITIONS | Evolved by Nature, Inc. (US) | 2022-06-29 | — | — | EP | disclosed |
| EP-0079611-A2 | Oral compositions containing strontium EDTA complex and soluble fluoride | Richardson-Vicks, Inc. (US) | 1983-05-25 | — | — | EP | disclosed |
| EP-0079611-A2 | Oral compositions containing strontium EDTA complex and soluble fluoride | Richardson-Vicks, Inc. (US) | 1983-05-25 | — | — | EP | disclosed |
| US-4367219-A | STRONTIUM ETHYLENEDIAMINE TETRAACETATE | SCHOLE MURRAY L | 1983-01-04 | — | — | US | disclosed |
| US-4367219-A | STRONTIUM ETHYLENEDIAMINE TETRAACETATE | SCHOLE MURRAY L | 1983-01-04 | — | — | US | disclosed |
| US-RE30675-E | DISODIUM STRONTIUM COMPLEX OF EDTA AND A RICINOLEATE | Schole, Murray L. (US) | 1981-07-14 | — | — | US | disclosed |
| US-4175120-A | CONTAINING STRONTIUM EDATE AND A RICINOLEATE | SCHOLE MURRAY L | 1979-11-20 | — | — | US | disclosed |
| US-3988434-A | IONIC STRONTIUM CHELATE OF ETHYLENEDIAMINETETRAACETIC ACID | SCHOLE MURRAY L | 1976-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230255857-A1 | DENTAL COMPOSITION CONTAINING ION SUSTAINED-RELEASE GLASS | SLCO2B1, CA2, SLCO2A1 | KDM4E 4266/4885ALOX15 1220/4885MAPT 3639/4885 |
| US-11559471-B2 | Dental composition containing ion sustained-release glass | SLCO2B1, CA2, SLCO2A1 | KDM4E 4266/4885ALOX15 1220/4885MAPT 3639/4885 |
| US-11648184-B2 | Dental composition containing ion sustained-release glass | SLCO2B1, CA2, SLCO2A1 | KDM4E 4266/4885ALOX15 1220/4885MAPT 3639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.