Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | KCNA4 | P22459 | 1/20 | 0.31 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.31 |
| ▸ | KCNAB1 | Q14722 | 1/20 | 0.31 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18119744 | 0.83 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9AMAPK1MEN1 | |
| SCHEMBL8585971 | 0.82 | ALDH1A1 (0.37) | SMN1; SMN2NPC1RAB9AMAPK1MEN1 | |
| SCHEMBL19923127 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9AMAPK1MEN1 | |
| SCHEMBL18119746 | 0.77 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9AMAPK1MEN1 | |
| SCHEMBL11460056 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AMAPK1MEN1 | |
| SCHEMBL13558669 | 0.75 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9AMAPK1MEN1 | |
| SCHEMBL9636744 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9AMAPK1MEN1 | |
| SCHEMBL1179726 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9AMAPK1MEN1 | |
| SCHEMBL9946118 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9AMAPK1MEN1 | |
| SCHEMBL4261995 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9AMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298291-A2 | Kinase inhibitors for treating cancers | Agennix USA Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2298291-A2 | Kinase inhibitors for treating cancers | Agennix USA Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2298292-A2 | Kinase inhibitors for treating cancers | Agennix USA Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2298292-A2 | Kinase inhibitors for treating cancers | Agennix USA Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| US-7893057-B2 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | AGENNIX USA INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-7893057-B2 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | AGENNIX USA INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-7893057-B2 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | AGENNIX USA INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-7786112-B2 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | AGENNIX USA INC. (US) | 2010-08-31 | — | — | US | disclosed |
| US-7786112-B2 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | AGENNIX USA INC. (US) | 2010-08-31 | — | — | US | disclosed |
| US-7786112-B2 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | AGENNIX USA INC. (US) | 2010-08-31 | — | — | US | disclosed |
| EP-2027853-A2 | Kinase inhibitors for treating cancers | GPC Biotech Inc. (US) | 2009-02-25 | — | — | EP | disclosed |
| US-20080146555-A1 | Uses of Kinase Inhibitors and Compositions Thereof | GPC BIOTECH, INC (US) | 2008-06-19 | — | — | US | disclosed |
| US-20080146555-A1 | Uses of Kinase Inhibitors and Compositions Thereof | GPC BIOTECH, INC (US) | 2008-06-19 | — | — | US | disclosed |
| US-20080146555-A1 | Uses of Kinase Inhibitors and Compositions Thereof | GPC BIOTECH, INC (US) | 2008-06-19 | — | — | US | disclosed |
| EP-1763345-A2 | KINASE INHIBITORS FOR TREATING CANCERS | GPC Biotech Inc. (US) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006002119-A2 | KINASE INHIBITORS FOR TREATING CANCERS | GPC BIOTECH, INC. (US) | 2006-01-05 | — | — | WO | disclosed |
| EP-1611136-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASES, COMPOSITIONS AND USES RELATED THERETO | GPC Biotech Inc. (US) | 2006-01-04 | — | — | EP | disclosed |
| US-20040266854-A1 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | GPC BIOTECH, INC. (US) | 2004-12-30 | — | — | US | disclosed |
| US-20040266853-A1 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | GPC BIOTECH, INC. (US) | 2004-12-30 | — | — | US | disclosed |
| WO-2004092139-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASES, COMPOSITIONS AND USES RELATED THERETO | GPC BIOTECH, INC. (US) | 2004-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266853-A1 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | CDK1, CCNO, CCNI | SMN1; SMN2 4027/4885NPC1 3626/4885RAB9A 2998/4885 |
| US-20080146555-A1 | Uses of Kinase Inhibitors and Compositions Thereof | CCNK, CDK3, CDK6 | SMN1; SMN2 2602/4885NPC1 3881/4885RAB9A 2051/4885 |
| US-20040266854-A1 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | CDK1, CCNO, CCNI | SMN1; SMN2 4027/4885NPC1 3626/4885RAB9A 2998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.