Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TCF4 | P15884 | 2/20 | 0.54 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3640218 | 0.93 | AKR1C3 (0.58) | EGFRCA1CA2SMN1; SMN2TP53 | |
| SCHEMBL1179635 | 0.84 | EGFR (0.56) | EGFRCA1CA2SMN1; SMN2TP53 | |
| SCHEMBL15761745 | 0.78 | HIF1A (0.65) | EGFRCA1CA2SMN1; SMN2TP53 | |
| SCHEMBL22887206 | 0.76 | SMN1; SMN2 (0.70) | SMN1; SMN2TP53MAPK1RAB9AALDH1A1 | |
| SCHEMBL11070204 | 0.75 | KDM4E (0.54) | CA1CA2MAPK1RAB9AALDH1A1 | |
| SCHEMBL13830752 | 0.74 | EGFR (0.62) | EGFRCA1CA2MAPK1RAB9A | |
| SCHEMBL5928456 | 0.74 | SMN1; SMN2 (0.71) | SMN1; SMN2TP53TCF4CTNNB1MAPK1 | |
| SCHEMBL29879594 | 0.74 | CA1 (0.61) | CA1CA2SMN1; SMN2TP53MAPK1 | |
| SCHEMBL15761718 | 0.74 | HIF1A (0.70) | CA1CA2TCF4CTNNB1ALDH1A1 | |
| SCHEMBL15761747 | 0.74 | CA1 (0.61) | CA1CA2SMN1; SMN2TP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110034507-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2011-02-10 | — | — | US | disclosed |
| EP-2173174-A1 | FARNESOID X RECEPTOR AGONISTS | GlaxoSmithKline LLC (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009005998-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034507-A1 | FARNESOID X RECEPTOR AGONISTS | NR1H4, NR1H3, NR1H2 | EGFR 2004/4885CA1 4660/4885CA2 4242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.