Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN2A | Q99250 | 7/20 | 0.56 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.56 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.52 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.52 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.50 |
| ▸ | HPGDS | O60760 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1181006 | 0.94 | SCN2A (0.56) | SCN2ANPY5RHSD17B1HSD17B2HPGDS | |
| SCHEMBL1180501 | 0.84 | SCN2A (0.64) | SCN2ANPY5RSMPD3HPGDS | |
| SCHEMBL27832173 | 0.83 | NPY5R (0.63) | NPY5RHPGDS | |
| SCHEMBL31660113 | 0.83 | CNR1 (0.54) | SCN2ANPY5RHSD17B1HSD17B2SMPD3 | |
| SCHEMBL26095410 | 0.83 | CNR1 (0.54) | SCN2ANPY5RHSD17B1HSD17B2SMPD3 | |
| SCHEMBL19443320 | 0.80 | SCN2A (0.49) | SCN2ANPY5RSMPD3HPGDS | |
| SCHEMBL26094287 | 0.77 | SCN2A (0.73) | SCN2ANPY5RSMPD3HPGDS | |
| SCHEMBL31087977 | 0.77 | SMPD3 (0.51) | HSD17B1HSD17B2SMPD3 | |
| SCHEMBL26095330 | 0.77 | TRPV1 (0.65) | SCN2ANPY5RSMPD3HPGDS | |
| SCHEMBL27832174 | 0.76 | NPY5R (0.67) | SCN2ANPY5RHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046147-A1 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-RELATED DISEASES | UNIVERSITAT DES SAARLANDES (DE) | 2011-02-24 | — | — | US | claimed |
| EP-2190421-A2 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-DEPENDENT DISEASES | Universität des Saarlandes (DE) | 2010-06-02 | — | — | EP | claimed |
| WO-2009027346-A2 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-DEPENDENT DISEASES | Universität des Saarlandes (DE) | 2009-03-05 | — | — | WO | claimed |
| US-20110046147-A1 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-RELATED DISEASES | UNIVERSITAT DES SAARLANDES (DE) | 2011-02-24 | — | — | US | disclosed |
| US-20110046147-A1 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-RELATED DISEASES | UNIVERSITAT DES SAARLANDES (DE) | 2011-02-24 | — | — | US | disclosed |
| US-20110046147-A1 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-RELATED DISEASES | UNIVERSITAT DES SAARLANDES (DE) | 2011-02-24 | — | — | US | disclosed |
| EP-2190421-A2 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-DEPENDENT DISEASES | Universität des Saarlandes (DE) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009027346-A2 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-DEPENDENT DISEASES | Universität des Saarlandes (DE) | 2009-03-05 | — | — | WO | disclosed |
| WO-2009027346-A2 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-DEPENDENT DISEASES | Universität des Saarlandes (DE) | 2009-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046147-A1 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-RELATED DISEASES | HSD17B1, HSD17B11, HSD17B2 | SCN2A 2366/4885NPY5R 4141/4885HSD17B1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.