SCHEMBL11801366

SCHEMBL11801366

COCOC(=O)C1=C(C)CS[C@@H]2C(NC(=O)Cc3ccccc3)C(=O)N12

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.77
L3MBTL1 Q9Y468 1/20 0.77
MAPK1 P28482 2/20 0.74
PLCG1 P19174 1/20 0.71
TDP1 Q9NUW8 4/20 0.61
CTDSP1 Q9GZU7 1/20 0.58
MAPT P10636 2/20 0.57
POLB P06746 1/20 0.57
PKM P14618 1/20 0.57
HTT P42858 1/20 0.57
DUSP3 P51452 1/20 0.57
PTPN5 P54829 1/20 0.57
PTPN11 Q06124 1/20 0.57
CACNA1B Q00975 2/20 0.51
APBA1 Q02410 2/20 0.51
KMT2A Q03164 2/20 0.50
HSD17B10 Q99714 2/20 0.50
CYP2C19 P33261 2/20 0.50
BLM P54132 1/20 0.50
CYP3A4 P08684 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11801374 1.00 ALDH1A1 (0.77) ALDH1A1L3MBTL1MAPK1PLCG1TDP1
SCHEMBL11713533 0.91 MAPK1 (0.82) ALDH1A1L3MBTL1MAPK1PLCG1TDP1
SCHEMBL109267 0.91 MAPK1 (0.82) ALDH1A1L3MBTL1MAPK1PLCG1TDP1
SCHEMBL11582562 0.91 MAPK1 (0.82) ALDH1A1L3MBTL1MAPK1PLCG1TDP1
SCHEMBL11713539 0.91 MAPK1 (0.82) ALDH1A1L3MBTL1MAPK1PLCG1TDP1
SCHEMBL11582565 0.91 MAPK1 (0.82) ALDH1A1L3MBTL1MAPK1PLCG1TDP1
SCHEMBL11411672 0.90 PLCG1 (0.85) ALDH1A1L3MBTL1MAPK1PLCG1TDP1
SCHEMBL11411669 0.90 PLCG1 (0.85) ALDH1A1L3MBTL1MAPK1PLCG1TDP1
SCHEMBL11182329 0.90 PLCG1 (0.85) ALDH1A1L3MBTL1MAPK1PLCG1TDP1
SCHEMBL11182332 0.90 PLCG1 (0.85) ALDH1A1L3MBTL1MAPK1PLCG1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3932392-A DICYCLOHEXYLAMINE, DIISOPROPYLAMINE BRISTOL-MYERS COMPANY (US) 1976-01-13 US disclosed