Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 2/20 | 0.54 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.51 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.51 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.51 |
| ▸ | QPCT | Q16769 | 1/20 | 0.51 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.51 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1179756 | 0.88 | IDO1 (0.55) | IDO1YTHDC1NR1H4SMN1; SMN2HSD17B10 | |
| SCHEMBL13085846 | 0.86 | IDO1 (0.64) | IDO1CDYL2CDYLCDY1; CDY1BYTHDC1 | |
| SCHEMBL7814456 | 0.82 | FGFR1 (0.64) | PPARGFGFR1 | |
| SCHEMBL6047768 | 0.81 | CYP11B1 (0.60) | QPCTQPCTLSMN1; SMN2HSD17B10LMNA | |
| SCHEMBL14376815 | 0.79 | HDAC6 (0.65) | QPCTQPCTL | |
| SCHEMBL14376802 | 0.79 | HDAC6 (0.53) | EPHX2PPARGQPCTQPCTLSMN1; SMN2 | |
| SCHEMBL8042067 | 0.77 | PPARG (0.60) | PPARGIDO1YTHDC1SMN1; SMN2MAPK1 | |
| SCHEMBL14976924 | 0.76 | BRD4 (0.54) | PPARGIDO1YTHDC1SMN1; SMN2KDM4E | |
| SCHEMBL17807884 | 0.75 | BRD4 (0.59) | IDO1SMN1; SMN2ALDH1A1FGFR1 | |
| SCHEMBL30202437 | 0.75 | BRD4 (0.59) | IDO1SMN1; SMN2ALDH1A1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110034507-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2011-02-10 | — | — | US | disclosed |
| US-20110034507-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2011-02-10 | — | — | US | disclosed |
| EP-2173174-A1 | FARNESOID X RECEPTOR AGONISTS | GlaxoSmithKline LLC (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009005998-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034507-A1 | FARNESOID X RECEPTOR AGONISTS | NR1H4, NR1H3, NR1H2 | EPHX2 1324/4885PPARG 38/4885IDO1 3242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.