⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11965638 | 1.00 | — | — | |
| SCHEMBL11809406 | 1.00 | — | — | |
| SCHEMBL11856272 | 0.79 | TDP1 (0.35) | — | |
| SCHEMBL11856278 | 0.79 | TDP1 (0.35) | — | |
| SCHEMBL19019192 | 0.79 | TDP1 (0.35) | — | |
| SCHEMBL1579883 | 0.76 | CYP2C9 (0.55) | — | |
| SCHEMBL18959027 | 0.76 | MEN1 (0.34) | — | |
| SCHEMBL1579884 | 0.76 | CYP2C9 (0.55) | — | |
| SCHEMBL16646930 | 0.76 | EGFR (0.32) | — | |
| SCHEMBL1959929 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154282-A1 | COMPOUNDS HAVING A T-STRUCTURE FORMED BY AT LEAST FOUR CYCLES FOR USE IN THE TREATMENT OF CANCER AND OTHER INDICATIONS | THERAS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |
| US-20230143040-A1 | PROCESS FOR PREPARING 5-(FLUORO-4-IMINO-3-METHYL)-1-TOSYL-3,4 DIHYDROPYRIMIDINE-(1H)-ONE AND DERIVATIVES OF THE COMPOUND | ADAMA MAKHTESHIM LTD. (IL) | 2023-05-11 | — | — | US | disclosed |
| WO-2023069959-A1 | COVALENT EGFR INHIBITORS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-04-27 | — | — | WO | disclosed |
| US-9810690-B2 | Method for screening inhibitors of Ras | ARAXES PHARMA LLC (US) | 2017-11-07 | — | — | US | disclosed |
| US-20170247391-A1 | THIENOPYRIMIDINE AND THIENOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF | WELLSPRING BIOSCIENCES LLC | 2017-08-31 | — | — | US | disclosed |
| US-20170131278-A1 | METHOD FOR SCREENING INHIBITORS OF RAS | ARAXES PHARMA LLC | 2017-05-11 | — | — | US | disclosed |
| US-9359327-B2 | Process for the preparation of substituted pyrimidine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2016-06-07 | — | — | US | disclosed |
| US-9079882-B2 | Process for the preparation of substituted pyrimidine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2015-07-14 | — | — | US | disclosed |
| US-9079883-B2 | Process for the preparation of substituted pyrimidine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2015-07-14 | — | — | US | disclosed |
| US-9079884-B2 | Process for the preparation of substituted pyrimidine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2015-07-14 | — | — | US | disclosed |
| WO-2014093230-A2 | COMPOSITIONS AND METHODS FOR THE PRODUCTION OF PYRIMIDINE AND PYRIDINE COMPOUNDS WITH BTK INHIBITORY ACTIVITY | MERCK PATENT GMBH (DE) | 2014-06-19 | — | — | WO | disclosed |
| US-20140121374-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRIMIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (US) | 2014-05-01 | — | — | US | disclosed |
| US-20140073795-A1 | Process for the preparation of substituted pyrimidine derivatives | JANSSEN PHARMACEUTICA NV (US) | 2014-03-13 | — | — | US | disclosed |
| US-20140066624-A1 | Process for the preparation of substituted pyrimidine derivatives | JANSSEN PHARMACEUTICA NV (US) | 2014-03-06 | — | — | US | disclosed |
| US-20130274212-A1 | Sesterterpene Compounds and Use Thereof | SNU R&DB FOUNDATION (KR) | 2013-10-17 | — | — | US | disclosed |
| US-20130225816-A1 | Process for the preparation of substituted pyrimidine derivatives | JANSSEN PHARMACEUTICA NV (US) | 2013-08-29 | — | — | US | disclosed |
| US-20130053561-A1 | Process for the preparation of substituted pyrimidine derivatives | JANSSEN PHARMACEUTICA NV (US) | 2013-02-28 | — | — | US | disclosed |
| US-8309720-B2 | Process for the preparation of substituted pyrimidine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2012-11-13 | — | — | US | disclosed |
| US-20100004450-A1 | Process for the preparation of substituted pyrimidine derivatives | CESCO-CANCIAN SERGIO | 2010-01-07 | — | — | US | disclosed |
| US-3954811-A | PROSTAGLANDIN INTERMEDIATES | SUMITOMO CHEMICAL CO., LTD. (JA) | 1976-05-04 | — | — | US | disclosed |