Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 5/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | PER2 | O15055 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11824158 | 0.80 | DRD2 (0.54) | SLC6A4MEN1KMT2AHSD17B10ALDH1A1 | |
| SCHEMBL3858428 | 0.76 | MCHR1 (0.52) | CYP1A2CYP2D6SLC6A4 | |
| SCHEMBL26837265 | 0.75 | SLC6A4 (0.45) | CYP1A2CYP2D6SLC6A4MEN1KMT2A | |
| SCHEMBL13877240 | 0.75 | SLC6A4 (0.46) | CYP1A2CYP2D6SLC6A4MEN1KMT2A | |
| SCHEMBL11818855 | 0.74 | CYP1A2 (0.63) | CYP1A2CYP2D6MEN1KMT2AHSD17B10 | |
| SCHEMBL3857871 | 0.73 | SLC6A4 (0.46) | CYP1A2CYP2D6SLC6A4MEN1KMT2A | |
| SCHEMBL11823048 | 0.72 | CYP1A2 (0.61) | CYP1A2CYP2D6MEN1KMT2AHSD17B10 | |
| SCHEMBL3857346 | 0.72 | MCHR1 (0.52) | CYP1A2CYP2D6SLC6A4 | |
| SCHEMBL10689191 | 0.71 | SLC6A4 (0.46) | CYP1A2CYP2D6SLC6A4MEN1KMT2A | |
| SCHEMBL3859870 | 0.71 | SLC6A4 (0.57) | CYP1A2CYP2D6SLC6A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3943148-A | Indole fused heterocyclic diuretic compounds | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-03-09 | — | — | US | claimed |
| US-3943148-A | Indole fused heterocyclic diuretic compounds | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-03-09 | — | — | US | disclosed |