Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13074767 | 0.80 | ROCK2 (0.80) | ROCK2ROCK1 | |
| SCHEMBL13074678 | 0.74 | ROCK2 (0.77) | ROCK2ROCK1 | |
| SCHEMBL118247 | 0.73 | ROCK2 (0.59) | ROCK2ROCK1 | |
| SCHEMBL19921898 | 0.72 | ROCK2 (0.75) | ROCK2ROCK1 | |
| SCHEMBL116119 | 0.71 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL169302 | 0.71 | ROCK2 (0.51) | ROCK2ROCK1 | |
| SCHEMBL22002322 | 0.70 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL13074677 | 0.69 | ROCK2 (0.78) | ROCK2ROCK1 | |
| SCHEMBL21680089 | 0.69 | ROCK2 (0.73) | ROCK2ROCK1 | |
| SCHEMBL118245 | 0.68 | ROCK2 (0.52) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424857-A1 | DUAL-ACTION INHIBITORS AND METHODS OF USING SAME | Aerie Pharmaceuticals, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010127329-A1 | DUAL-ACTION INHIBITORS AND METHODS OF USING SAME | AERIE PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010127330-A1 | DUAL-ACTION INHIBITORS AND METHODS OF USING SAME | AERIE PHAMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |