Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.48 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8387215 | 0.90 | AKR1C3 (0.46) | AKR1C3AKR1C2AKR1C4PTGS1AKR1C1 | |
| SCHEMBL11844808 | 0.88 | AKR1C3 (0.60) | AKR1C3AKR1C2AKR1C4PTGS1AKR1C1 | |
| SCHEMBL11841099 | 0.87 | AKR1C3 (0.45) | AKR1C3AKR1C2AKR1C4PTGS1AKR1C1 | |
| SCHEMBL11836432 | 0.86 | EGFR (0.39) | AKR1C3AKR1C2AKR1C4PTGS1AKR1C1 | |
| SCHEMBL11848814 | 0.86 | AKR1C3 (0.45) | AKR1C3AKR1C2AKR1C4PTGS1AKR1C1 | |
| SCHEMBL11837921 | 0.85 | AKR1C3 (0.57) | AKR1C3AKR1C2AKR1C4PTGS1AKR1C1 | |
| SCHEMBL11836306 | 0.85 | AKR1C3 (0.48) | AKR1C3AKR1C2AKR1C4PTGS1AKR1C1 | |
| SCHEMBL11835699 | 0.84 | AKR1C3 (0.42) | AKR1C3AKR1C2AKR1C4PTGS1AKR1C1 | |
| SCHEMBL11843978 | 0.84 | AKR1C3 (0.54) | AKR1C3AKR1C2AKR1C4PTGS1AKR1C1 | |
| SCHEMBL11834239 | 0.83 | AKR1C3 (0.55) | AKR1C3AKR1C2AKR1C4PTGS1AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3948939-A | 9-Acyl-1,2,3,4-tetrahydrocarbazole-3 and 4-carboxylic acids | STERLING DRUG INC. (US) | 1976-04-06 | — | — | US | disclosed |