Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL117685 | 0.86 | ACE2 (0.44) | MAPTTP53RXFP1ABCG2KDM4E | |
| SCHEMBL3723524 | 0.84 | TP53 (0.53) | MAPTTP53RXFP1ABCG2KDM4E | |
| SCHEMBL16150328 | 0.83 | TP53 (0.58) | MAPTTP53RXFP1ABCG2KDM4E | |
| SCHEMBL3724874 | 0.83 | TP53 (0.52) | MAPTTP53RXFP1ABCG2KDM4E | |
| SCHEMBL4167435 | 0.82 | ABCG2 (0.70) | MAPTTP53RXFP1ABCG2KDM4E | |
| SCHEMBL118463 | 0.82 | ACE2 (0.58) | MAPTABCG2ACE2PPARG | |
| SCHEMBL4158838 | 0.81 | TP53 (0.56) | MAPTTP53RXFP1ABCG2KDM4E | |
| SCHEMBL13056297 | 0.80 | MAPT (0.54) | MAPTTP53RXFP1ABCG2KDM4E | |
| SCHEMBL4158840 | 0.80 | TP53 (0.55) | MAPTTP53RXFP1ABCG2KDM4E | |
| SCHEMBL13056294 | 0.80 | MAPT (0.53) | MAPTTP53RXFP1ABCG2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424541-A2 | PHOSPHORYLATED AND PHOSPHONATED PYRONE ANALOGS FOR THERAPEUTIC TREATMENT | Limerick BioPharma, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |