Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.47 |
| ▸ | POLH | Q9Y253 | 3/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174699 | 0.90 | ADORA3 (0.60) | ACE2ADORA3PPARGABCB1POLH | |
| SCHEMBL117685 | 0.89 | ACE2 (0.44) | ACE2PPARGABCG2MAPT | |
| SCHEMBL3650410 | 0.87 | ACE2 (0.58) | ACE2ADORA3PPARGABCG2ABCB1 | |
| SCHEMBL1421560 | 0.87 | ACE2 (0.69) | ACE2ADORA3PPARGABCG2ABCB1 | |
| SCHEMBL119974 | 0.85 | ACE2 (0.60) | ACE2ADORA3PPARGABCG2ABCB1 | |
| SCHEMBL13056281 | 0.84 | ACE2 (0.63) | ACE2ADORA3PPARGABCG2ABCB1 | |
| SCHEMBL118391 | 0.83 | ADORA3 (0.61) | ACE2ADORA3PPARGABCG2ABCB1 | |
| SCHEMBL29410971 | 0.83 | ADORA3 (0.61) | ACE2ADORA3PPARGABCG2ABCB1 | |
| SCHEMBL25299409 | 0.83 | ACE2 (0.73) | ACE2ADORA3PPARGABCG2ABCB1 | |
| SCHEMBL3649419 | 0.82 | ACE2 (0.56) | ACE2ADORA3PPARGABCG2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424541-A2 | PHOSPHORYLATED AND PHOSPHONATED PYRONE ANALOGS FOR THERAPEUTIC TREATMENT | Limerick BioPharma, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |