Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30679030 | 0.87 | MAPT (0.57) | MAPTALDH1A1NPC1LMNAHTT | |
| SCHEMBL5309365 | 0.87 | HIF1A (0.63) | MAPTALDH1A1LMNAHTTKDM4E | |
| SCHEMBL14243556 | 0.83 | HDAC1 (0.53) | MAPTALDH1A1HTTPDGFRBPDGFRA | |
| SCHEMBL28532163 | 0.83 | PTPN7 (0.58) | MAPTALDH1A1KDM4EMEN1GAA | |
| SCHEMBL27501391 | 0.83 | SMN1; SMN2 (0.57) | MAPTHTTKDM4EMEN1KMT2A | |
| SCHEMBL27526149 | 0.83 | MAPT (0.51) | MAPTALDH1A1NPC1LMNAHTT | |
| SCHEMBL11176623 | 0.81 | MAPT (0.65) | MAPTALDH1A1NPC1LMNAHTT | |
| SCHEMBL5841682 | 0.80 | TUBB4A (0.59) | MAPTALDH1A1NPC1LMNAHTT | |
| SCHEMBL31527666 | 0.79 | TUBB4A (0.69) | MAPTALDH1A1HTTKDM4EMEN1 | |
| SCHEMBL30691761 | 0.79 | MAPT (0.52) | MAPTALDH1A1NPC1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3979391-A | 1,2,3,4-Tetrahydrocarbazoles | STERLING DRUG INC. (US) | 1976-09-07 | — | — | US | disclosed |
| US-3939177-A | 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles | STERLING DRUG INC. (US) | 1976-02-17 | — | — | US | disclosed |