Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11863329 | 1.00 | KDM4E (0.71) | KDM4EALDH1A1MAPTL3MBTL1MCL1 | |
| SCHEMBL3327919 | 0.98 | KDM4E (0.73) | KDM4EALDH1A1MAPTL3MBTL1MCL1 | |
| SCHEMBL11838776 | 0.94 | KDM4E (0.66) | KDM4EALDH1A1MAPTL3MBTL1MCL1 | |
| SCHEMBL11838741 | 0.90 | KDM4E (0.62) | KDM4EALDH1A1MAPTL3MBTL1MCL1 | |
| SCHEMBL11867505 | 0.85 | RAB9A (0.53) | KDM4EALDH1A1MAPTL3MBTL1MCL1 | |
| SCHEMBL11866852 | 0.85 | RAB9A (0.53) | KDM4EALDH1A1MAPTL3MBTL1NPC1 | |
| SCHEMBL11877408 | 0.85 | RAB9A (0.53) | KDM4EALDH1A1MAPTL3MBTL1NPC1 | |
| SCHEMBL11840427 | 0.84 | NPC1 (0.56) | KDM4EALDH1A1MAPTL3MBTL1MCL1 | |
| SCHEMBL11828712 | 0.83 | RAB9A (0.55) | KDM4EALDH1A1MAPTL3MBTL1MCL1 | |
| SCHEMBL11831088 | 0.83 | NPC1 (0.74) | KDM4EALDH1A1MAPTL3MBTL1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3997557-A | ANTIARRHYTHMIA, CNS DEPRESSANT, ANTIINFLAMMATORY, HYPOTENSIVE | AMERICAN HOECHST CORPORATION (US) | 1976-12-14 | — | — | US | disclosed |
| US-3931407-A | ANTIINFLAMMATORY, ANALGESIC | AMERICAN HOECHST CORPORATION (US) | 1976-01-06 | — | — | US | disclosed |