Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | NOS2 | P35228 | 2/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL606148 | 0.92 | MAPT (0.57) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL2860350 | 0.88 | MAPK1 (0.58) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL4716807 | 0.87 | MAPT (0.67) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL8672067 | 0.86 | MAPT (0.69) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL15319957 | 0.86 | MAPT (0.66) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL11026402 | 0.85 | MAPT (0.67) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL11851098 | 0.83 | LMNA (0.55) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL7188349 | 0.82 | MAPK1 (0.54) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL7188345 | 0.82 | MAPK1 (0.54) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL22605900 | 0.82 | MAPK1 (0.63) | MAPTALDH1A1MAPK1NPSR1STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3989707-A | NEUROLEPTIC AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1976-11-02 | — | — | US | disclosed |