Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.50 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.50 |
| ▸ | KMT5A | Q9NQR1 | 15/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11852328 | 0.92 | HTT (0.61) | HTTEHMT2EHMT1KMT5APDE5A | |
| Nitric Acid SCHEMBL11849862 | 0.89 | HTT (0.49) | HTTEHMT2EHMT1KMT5AKDM1A | |
| Nitric Acid SCHEMBL11849851 | 0.89 | HTT (0.49) | HTTEHMT2EHMT1KMT5AKDM1A | |
| SCHEMBL11851777 | 0.86 | PDE5A (0.57) | HTTKMT5APDE5AENPP1 | |
| Nitric Acid SCHEMBL11852923 | 0.84 | PDE5A (0.65) | HTTEHMT2EHMT1PDE5A | |
| Nitric Acid SCHEMBL11853781 | 0.84 | PDE5A (0.65) | HTTEHMT2EHMT1PDE5A | |
| SCHEMBL23260582 | 0.82 | EHMT2 (0.54) | HTTEHMT2EHMT1KMT5A | |
| SCHEMBL11855175 | 0.81 | HTT (0.56) | HTTEHMT2EHMT1KMT5AKDM1A | |
| SCHEMBL11849858 | 0.80 | KMT5A (0.45) | HTTEHMT2KMT5APDE5AKDM1A | |
| Nitric Acid SCHEMBL11757264 | 0.76 | HTR1A (0.53) | EHMT2EHMT1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3954987-A | 2-Alkyl-4-substituted amino-quinazolines and nitrates thereof in the treatment of myocardial shock | SANDOZ, INC. (US) | 1976-05-04 | — | — | US | disclosed |