⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL575814 | 1.00 | CRBN (0.65) | — | |
| SCHEMBL27172945 | 1.00 | CRBN (0.65) | — | |
| SCHEMBL21978874 | 0.88 | CRBN (0.56) | — | |
| SCHEMBL6365823 | 0.87 | CRBN (0.85) | — | |
| SCHEMBL16431244 | 0.83 | OR51E2 (0.79) | — | |
| SCHEMBL21473988 | 0.83 | OR51E2 (0.79) | — | |
| SCHEMBL24827100 | 0.80 | CRBN (0.47) | — | |
| SCHEMBL42430 | 0.80 | — | — | |
| Diketopiperazine SCHEMBL66638 | 0.80 | — | — | |
| SCHEMBL23975525 | 0.80 | CRBN (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090104116-A1 | COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF | JERINI AG (DE) | 2009-04-23 | — | — | US | claimed |
| EP-1979342-A1 | COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF | Jerini AG (DE) | 2008-10-15 | — | — | EP | claimed |
| WO-2007088041-A1 | COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF | JERINI AG (DE) | 2007-08-09 | — | — | WO | claimed |
| CN-116785449-A | Benzopyrrolopyrrole heterocyclic compound and conjugate thereof, preparation method and application thereof | 江苏恒瑞医药股份有限公司 | 2023-09-22 | — | — | CN | disclosed |
| EP-2805732-B1 | Polymer-drug conjugates for the treatment of amyloidosis | FUNDACIÓN COMUNIDAD VALENCIANA CT DE INVESTIGACIÓN PRINCIPE FELIPE (ES) | 2016-09-28 | — | — | EP | disclosed |
| US-20160114055-A1 | POLYMER DRUG CONJUGATES FOR THE TREATMENT OF AMYLOIDOSIS | FUNDACION DE LA COMUNIDAD VALENCIANA "CENTRO DE INVESTIGACIONES PRINCIPE FELIPE" (ES) | 2016-04-28 | — | — | US | disclosed |
| EP-2518056-B1 | SEVEN-MEMBERED RING COMPOUND AND PHARMACEUTICAL USE THEREFOR | DAIICHI SANKYO CO LTD (JP) | 2015-07-29 | — | — | EP | disclosed |
| US-9040701-B2 | Apaf-1 inhibitor compounds | LABORATORIOS SALVAT, S.A. (ES) | 2015-05-26 | — | — | US | disclosed |
| US-8927534-B2 | Compounds for the inhibition of integrins and use thereof | SHIRE ORPHAN THERAPIES GMBH (DE) | 2015-01-06 | — | — | US | disclosed |
| EP-2805732-A1 | Polymer-drug conjugates for the treatment of amyloidosis | Fundación Comunidad Valenciana Centro de Investigación Principe Felipe (ES) | 2014-11-26 | — | — | EP | disclosed |
| US-8846660-B2 | Seven-membered ring compound and pharmaceutical use therefor | DAIICHI SANKYO COMPANY, LTD. (JP) | 2014-09-30 | — | — | US | disclosed |
| US-20060189591-A1 | Five-membered heterocyclic derivative | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-08-24 | — | — | US | disclosed |
| US-20060128685-A1 | Pyrazole derivative | DAIICHI PHARMACEUTICAL CO., LTD., (JP) | 2006-06-15 | — | — | US | disclosed |
| EP-1621537-A1 | FIVE-MEMBERED HETEROCYCLIC DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-02-01 | — | — | EP | disclosed |
| EP-1591443-A1 | PYRAZOLE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2005-11-02 | — | — | EP | disclosed |
| CN-1178923-C | 1, 4-diazepan-2, 5-dione derivatives and their use as NK-1 receptor antagonists | - | 2004-12-08 | — | — | CN | disclosed |
| EP-1472377-A2 | GENETIC POLYMORPHISMS IN THE PREPROTACHYKININ GENE | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-03 | — | — | EP | disclosed |
| US-20030158187-A1 | Isolated nucleic acids, a diagnostic kit, sequence identification, gene sequence determination, a computer program with stored sequence information | F. HOFFMANN-LA ROCHE AG A SWISS COMPANY (CH) | 2003-08-21 | — | — | US | disclosed |
| WO-2003064685-A2 | GENETIC POLYMORPHISMS IN THE PREPROTACHYKININ GENE | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-07 | — | — | WO | disclosed |
| CN-1430611-A | 1, 4-diazepan-2, 5-dione derivatives and their use as NK-1 receptor antagonists | HOFFMANN LA ROCHE (CH) | 2003-07-16 | — | — | CN | disclosed |