Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 15/20 | 0.53 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11862007 | 0.90 | MAP2K4 (0.46) | CHEK1EIF2AK1PDGFRBMAP2K4KDR | |
| SCHEMBL11865766 | 0.81 | CHEK1 (0.68) | CHEK1PDGFRBKDR | |
| SCHEMBL4807175 | 0.79 | CHEK1 (0.69) | CHEK1 | |
| SCHEMBL11864274 | 0.78 | CHEK1 (0.78) | CHEK1PDGFRB | |
| SCHEMBL11862360 | 0.77 | CHEK1 (0.62) | CHEK1PDGFRBKDR | |
| SCHEMBL11865835 | 0.76 | KDR (0.78) | CHEK1PDGFRBKDR | |
| SCHEMBL11863990 | 0.75 | KDR (0.63) | CHEK1PDGFRBMAP2K4KDR | |
| SCHEMBL11862275 | 0.74 | CHEK1 (0.58) | CHEK1PDGFRBKDR | |
| SCHEMBL11865780 | 0.73 | CHEK1 (0.53) | CHEK1PDGFRBKDRCA1CA2 | |
| SCHEMBL11863997 | 0.70 | HIF1A (0.57) | CHEK1MAP2K4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3932430-A | Substituted indeno, naphtho and cyclohepta pyrazoles | SANDOZ, INC. (US) | 1976-01-13 | — | — | US | disclosed |