Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11863730 | 0.81 | MAPT (0.50) | KDM4EHTTMAPTMEN1KMT2A | |
| SCHEMBL6563800 | 0.80 | CYP1A2 (0.50) | MAPTKMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL17085323 | 0.78 | KDM4E (0.54) | KDM4EMAPTKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17085325 | 0.75 | KDM4E (0.42) | KDM4EMAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6565474 | 0.74 | ALOX5 (0.53) | KDM4EHTTMAPTMEN1KMT2A | |
| SCHEMBL11867394 | 0.73 | MAPT (0.52) | HTTMAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL6565637 | 0.72 | CYP1A2 (0.48) | HTTMAPTKMT2ACYP1A2CYP2C9 | |
| SCHEMBL11868068 | 0.71 | KDM4E (0.54) | KDM4EHTTMAPTMEN1KMT2A | |
| SCHEMBL11866701 | 0.71 | CA12 (0.62) | KDM4E | |
| SCHEMBL13752163 | 0.71 | KDM4E (0.60) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3974162-A | 4-Pyrimidinylthioacetic acid derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-08-10 | — | — | US | disclosed |