Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sotalol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 5/20 | 1.00 |
| ▸ | ADRB1 known ✓ | P08588 | 5/20 | 1.00 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | BLM | P54132 | 3/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.97 |
| ▸ | MEN1 | O00255 | 4/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.97 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexsotalol SCHEMBL5661932 | 1.00 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNABLM | |
| Sotalol SCHEMBL20575697 | 1.00 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNABLM | |
| Sotalol SCHEMBL29761416 | 0.98 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNABLM | |
| Sotalol SCHEMBL6508618 | 0.98 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNABLM | |
| Dexsotalol SCHEMBL203209 | 0.98 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNABLM | |
| Sotalol SCHEMBL16407 | 0.98 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNABLM | |
| Sotalol SCHEMBL3127442 | 0.95 | ADRB3 (0.94) | ADRB3ADRB2ADRB1LMNABLM | |
| Sotalol SCHEMBL3287528 | 0.95 | ADRB3 (0.94) | ADRB3ADRB2ADRB1LMNABLM | |
| Sotalol SCHEMBL1649808 | 0.95 | ADRB3 (0.94) | ADRB3ADRB2ADRB1LMNABLM | |
| Sotalol SCHEMBL29188242 | 0.90 | ADRB3 (0.84) | ADRB3ADRB2ADRB1LMNABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4203 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122075449-A | Soxotalol hydrochloride film agent for oral instant administration and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| US-20260137639-A1 | METHOD OF ADMINISTERING SOTALOL HYDROCHLORIDE FOR THE TREATMENT OF PEDIATRIC PATIENTS | AltaThera Pharmaceuticals LLC (US) | 2026-05-21 | — | — | US | claimed |
| CN-122059856-A | Preparation method of sotalol hydrochloride | 常州制药厂有限公司 | 2026-05-19 | — | — | CN | claimed |
| EP-4691556-A2 | HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF | H. Lundbeck A/S (DK) | 2026-02-11 | — | — | EP | claimed |
| US-20260034080-A1 | METHOD OF INITIATING SOTALOL HYDROCHLORIDE DOSING | AltaThera Pharmaceuticals LLC | 2026-02-05 | — | — | US | claimed |
| US-12403109-B2 | Sotalol hydrochloride dosing | AltaThera Pharmaceuticals LLC (US) | 2025-09-02 | — | — | US | claimed |
| US-20250264469-A1 | METHODS FOR IMPROVING OUTCOMES FOR HEMATOPOIETIC CELL TRANSPLANT RECIPIENTS AT RISK FOR BRONCHIOLITIS OBLITERANS SYNDROME | CHILDREN'S HOSPITAL MEDICAL CENTER | 2025-08-21 | — | — | US | claimed |
| US-12390431-B2 | Method of escalating sotalol hydrochloride dosing | AltaThera Pharmaceuticals LLC (US) | 2025-08-19 | — | — | US | claimed |
| US-20250213504-A1 | METHODS OF INTRAVENOUSLY ADMINISTERING SOTALOL HYDROCHLORIDE FOR THE TREATMENT OF PEDIATRIC PATIENTS | AltaThera Pharmaceuticals LLC (US) | 2025-07-03 | — | — | US | claimed |
| US-20250152530-A1 | SOTALOL HYDROCHLORIDE DOSING | AltaThera Pharmaceuticals LLC | 2025-05-15 | — | — | US | claimed |
| CN-1328453-A | Pharmaceutical composition comprising combination of dextro-and laevo-isomers of sotalol | TOLENTO MEDICINE CO LTD (IN) | 2001-12-26 | — | — | CN | claimed |
| WO-2001092283-A2 | COBALAMIN COMPOUNDS USEFUL AS CARDIOVASCULAR AGENTS AND AS IMAGING AGENTS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2001-12-06 | — | — | WO | claimed |
| US-20010046964-A1 | Timed pulsatile drug delivery systems | TEAL MIDCO HOLDINGS, L.P. | 2001-11-29 | — | — | US | claimed |
| WO-2001080824-A2 | DUAL MECHANISM TIMED RELEASE DOSAGE FORMS FOR LOW DOSE DRUGS | EURAND AMERICA, INC. (US) | 2001-11-01 | — | — | WO | claimed |
| EP-1146865-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A COMBINATION OF DEXTRO- AND LAEVO- ISOMERS OF SOTALOL | Torrent Pharmaceuticals Ltd (IN) | 2001-10-24 | — | — | EP | claimed |
| EP-1123700-A1 | Timed pulsatile drug delivery systems | EURAND AMERICA, INCORPORATED (US) | 2001-08-16 | — | — | EP | claimed |
| WO-2001058433-A1 | TIMED PULSATILE DRUG DELIVERY SYSTEMS | EURAND PHARMACEUTICALS LTD. (IE) | 2001-08-16 | — | — | WO | claimed |
| WO-2000069412-A1 | METHOD OF TREATING ANGINA AND/OR ANGINAL EQUIVALENTS, AND PHARMACEUTICAL COMPOSITIONS AND KIT RELATED THERETO | ESPERION LUV DEVELOPMENT, INC. (US) | 2000-11-23 | — | — | WO | claimed |
| WO-2000045807-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A COMBINATION OF DEXTRO- AND LAEVO- ISOMERS OF SOTALOL | SANKARANARAYANAN ALANGUDI (IN) | 2000-08-10 | — | — | WO | claimed |
| US-5484776-A | REACTION WITH POLYSACCHARIDE | SYNEPOS AKTIENGESELLSCHAFT (LI) | 1996-01-16 | — | — | US | claimed |