Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sotalol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 5/20 | 1.00 |
| ▸ | ADRB1 known ✓ | P08588 | 5/20 | 1.00 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | BLM | P54132 | 3/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.97 |
| ▸ | MEN1 | O00255 | 4/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.97 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sotalol SCHEMBL118761 | 1.00 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNABLM | |
| Dexsotalol SCHEMBL5661932 | 1.00 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNABLM | |
| Sotalol SCHEMBL29761416 | 0.98 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNABLM | |
| Sotalol SCHEMBL6508618 | 0.98 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNABLM | |
| Dexsotalol SCHEMBL203209 | 0.98 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNABLM | |
| Sotalol SCHEMBL16407 | 0.98 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNABLM | |
| Sotalol SCHEMBL3127442 | 0.95 | ADRB3 (0.94) | ADRB3ADRB2ADRB1LMNABLM | |
| Sotalol SCHEMBL3287528 | 0.95 | ADRB3 (0.94) | ADRB3ADRB2ADRB1LMNABLM | |
| Sotalol SCHEMBL1649808 | 0.95 | ADRB3 (0.94) | ADRB3ADRB2ADRB1LMNABLM | |
| Sotalol SCHEMBL29188242 | 0.90 | ADRB3 (0.84) | ADRB3ADRB2ADRB1LMNABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220133660-A1 | METHODS OF TREATMENT USING SUSTAINED RELEASE SOTALOL FORMULATIONS | THE ROSHNI SINGH 2015 TRUST (US) | 2022-05-05 | — | — | US | disclosed |
| US-10561625-B2 | Methods of treatment using sustained release sotalol formulations | THE ROSHNI SINGH 2015 TRUST (US) | 2020-02-18 | — | — | US | disclosed |
| US-20180344675-A1 | METHODS OF TREATMENT USING SUSTAINED RELEASE SOTALOL FORMULATIONS | THE ROSHNI SINGH 2015 TRUST (US) | 2018-12-06 | — | — | US | disclosed |