Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.78 |
| ▸ | LCK | P06239 | 8/20 | 0.78 |
| ▸ | TEK | Q02763 | 8/20 | 0.78 |
| ▸ | KDR | P35968 | 7/20 | 0.78 |
| ▸ | RAF1 | P04049 | 4/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.56 |
| ▸ | CSF1R | P07333 | 3/20 | 0.43 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2517955 | 0.88 | BRAF (1.00) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL11889293 | 0.87 | BRAF (0.76) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL5473933 | 0.85 | BRAF (0.60) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL22223986 | 0.80 | BRAF (0.71) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL11889285 | 0.80 | BRAF (0.66) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL11889511 | 0.79 | BRAF (0.83) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL11889394 | 0.79 | BRAF (0.83) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL11889300 | 0.79 | BRAF (0.83) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL11889023 | 0.79 | BRAF (0.83) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL11888951 | 0.78 | BRAF (0.84) | BRAFLCKTEKKDRRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976836-B9 | NITROGEN-CONTAINING BICYCLIC HETEROARYL COMPOUNDS FOR THE TREATMENT OF RAF PROTEIN KINASE-MEDIATED DISEASES | AMGEN INC (US) | 2013-02-06 | — | — | EP | disclosed |
| EP-1976836-B1 | NITROGEN-CONTAINING BICYCLIC HETEROARYL COMPOUNDS FOR THE TREATMENT OF RAF PROTEIN KINASE-MEDIATED DISEASES | AMGEN INC (US) | 2012-08-22 | — | — | EP | disclosed |
| EP-2481729-A1 | Nintrogen-containing bicyclic heteroaryl compounds for the treatment of RAF protein kinase-mediated diseases | Amgen Inc. (US) | 2012-08-01 | — | — | EP | disclosed |