Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.66 |
| ▸ | KDR | P35968 | 11/20 | 0.66 |
| ▸ | LCK | P06239 | 8/20 | 0.66 |
| ▸ | TEK | Q02763 | 7/20 | 0.66 |
| ▸ | RAF1 | P04049 | 3/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.51 |
| ▸ | CSF1R | P07333 | 3/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.42 |
| ▸ | FLT1 | P17948 | 7/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | HLA-A | P04439 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | FRK | P42685 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11889293 | 0.80 | BRAF (0.76) | BRAFKDRLCKTEKRAF1 | |
| SCHEMBL11889282 | 0.80 | BRAF (0.78) | BRAFKDRLCKTEKRAF1 | |
| SCHEMBL22223986 | 0.79 | BRAF (0.71) | BRAFKDRLCKTEKRAF1 | |
| SCHEMBL2517955 | 0.79 | BRAF (1.00) | BRAFKDRLCKTEKRAF1 | |
| SCHEMBL11889124 | 0.78 | BRAF (1.00) | BRAFKDRLCKTEKRAF1 | |
| SCHEMBL15215289 | 0.74 | BRAF (0.78) | BRAFKDRLCKTEKRAF1 | |
| SCHEMBL18155155 | 0.73 | BRAF (1.00) | BRAFKDRLCKTEKRAF1 | |
| SCHEMBL30499048 | 0.73 | BRAF (1.00) | BRAFKDRLCKTEKRAF1 | |
| Hydrochloric Acid SCHEMBL19873385 | 0.72 | BRAF (1.00) | BRAFKDRLCKTEKRAF1 | |
| Hydrochloric Acid SCHEMBL19873386 | 0.72 | BRAF (1.00) | BRAFKDRLCKTEKRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976836-B9 | NITROGEN-CONTAINING BICYCLIC HETEROARYL COMPOUNDS FOR THE TREATMENT OF RAF PROTEIN KINASE-MEDIATED DISEASES | AMGEN INC (US) | 2013-02-06 | — | — | EP | disclosed |
| EP-1976836-B1 | NITROGEN-CONTAINING BICYCLIC HETEROARYL COMPOUNDS FOR THE TREATMENT OF RAF PROTEIN KINASE-MEDIATED DISEASES | AMGEN INC (US) | 2012-08-22 | — | — | EP | disclosed |
| EP-2481729-A1 | Nintrogen-containing bicyclic heteroaryl compounds for the treatment of RAF protein kinase-mediated diseases | Amgen Inc. (US) | 2012-08-01 | — | — | EP | disclosed |