Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9132404 | 0.82 | MAPT (0.39) | SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8910489 | 0.76 | CYP2C19 (0.40) | SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL27192654 | 0.74 | HRH3 (0.40) | SMN1; SMN2KDM4EALDH1A1ACHE | |
| SCHEMBL8481040 | 0.73 | AKT1 (0.39) | SMN1; SMN2KDM4EALDH1A1MAPK14MAPK11 | |
| SCHEMBL2077345 | 0.71 | QDPR (0.50) | MAPK14MAPK11 | |
| SCHEMBL7137184 | 0.67 | HRH4 (0.41) | GAA | |
| SCHEMBL1935925 | 0.67 | HRH3 (0.58) | SMN1; SMN2 | |
| SCHEMBL12676793 | 0.67 | CARM1 (0.43) | SMN1; SMN2GAAMAPK14MAPK11 | |
| SCHEMBL14980372 | 0.67 | POLB (0.64) | — | |
| SCHEMBL8302436 | 0.67 | CYP19A1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971604-B1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | AMGEN INC (US) | 2012-08-01 | — | — | EP | disclosed |