Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.57 |
| ▸ | USP2 | O75604 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11889801 | 0.89 | MAPT (0.74) | MAPTUSP2HSD17B10TP53MAPK1 | |
| SCHEMBL2455257 | 0.85 | MAPT (0.64) | MAPTUSP2HSD17B10TP53MAPK1 | |
| SCHEMBL2454198 | 0.85 | MAPT (0.64) | MAPTUSP2HSD17B10TP53MAPK1 | |
| SCHEMBL2459317 | 0.85 | MAPT (0.57) | MAPTUSP2HSD17B10TP53MAPK1 | |
| SCHEMBL11889746 | 0.83 | MAPT (0.55) | MAPTUSP2HSD17B10TP53MAPK1 | |
| SCHEMBL11889651 | 0.83 | MAPT (0.65) | MAPTUSP2TP53MAPK1KDM4E | |
| SCHEMBL11889740 | 0.82 | MAPT (0.65) | MAPTUSP2HSD17B10TP53MAPK1 | |
| SCHEMBL12306055 | 0.81 | RAB9A (0.63) | MAPTUSP2HSD17B10KDM4ELMNA | |
| SCHEMBL11889725 | 0.81 | MAPT (0.56) | MAPTUSP2TP53MAPK1KDM4E | |
| SCHEMBL11889739 | 0.81 | CA12 (0.60) | MAPTUSP2MAPK1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101035777-B | HCV replication modulators | ANGELETTI P IST RICHERCHE BIO | 2013-01-02 | — | — | CN | disclosed |
| EP-1799663-B1 | Modulators of HCV replication | ANGELETTI P IST RICHERCHE BIO (IT) | 2012-08-01 | — | — | EP | disclosed |
| CN-101035777-A | HCV replication modulators | ANGELETTI P IST RICHERCHE BIO (IT) | 2007-09-12 | — | — | CN | disclosed |