SCHEMBL118919

SCHEMBL118919

O=C(O)N(C[C@@H](O)CCl)c1ccc(N2CCOCC2=O)cc1

nearest known ligand 0.42

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
F10 P00742 11/20 0.42
PTGS2 P35354 9/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7727831 0.87 PTGS2 (0.43) F10PTGS2
SCHEMBL118025 0.87 PTGS2 (0.43) F10PTGS2
SCHEMBL28409632 0.86 F10 (0.45) F10PTGS2
SCHEMBL16516169 0.83 PTGS2 (0.46) F10PTGS2
SCHEMBL16516170 0.83 PTGS2 (0.46) F10PTGS2
SCHEMBL2715335 0.83 F10 (0.41) F10PTGS2
SCHEMBL1176206 0.83 F10 (0.41) F10PTGS2
SCHEMBL19647431 0.80 F10 (0.41) F10PTGS2
SCHEMBL7722075 0.80 F10 (0.46) F10PTGS2
SCHEMBL7722226 0.80 F10 (0.46) F10PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2424847-B1 PROCESSES FOR THE PREPARATION OF RIVAROXABAN AND INTERMEDIATES THEREOF APOTEX PHARMACHEM INC (CA) 2016-04-06 EP disclosed
EP-2424847-A1 PROCESSES FOR THE PREPARATION OF RIVAROXABAN AND INTERMEDIATES THEREOF Apotex Pharmachem Inc. (CA) 2012-03-07 EP disclosed
WO-2010124385-A1 PROCESSES FOR THE PREPARATION OF RIVAROXABAN AND INTERMEDIATES THEREOF APOTEX PHARMACHEM INC. (CA) 2010-11-04 WO disclosed