Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.43 |
| ▸ | PIM1 | P11309 | 3/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.34 |
| ▸ | CDK9 | P50750 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11892633 | 0.92 | FLT3 (0.42) | FLT3PIM1PIM3PIM2RPS6KB1 | |
| SCHEMBL11892624 | 0.86 | FLT3 (0.43) | FLT3RPS6KB1AURKAAURKBMAPK1 | |
| SCHEMBL11892637 | 0.82 | RPS6KB1 (0.39) | RPS6KB1AURKAAURKBMAPK1 | |
| SCHEMBL10322937 | 0.81 | FLT3 (0.56) | FLT3PIM1CCNT1MAPK8MAPK9 | |
| SCHEMBL10353924 | 0.81 | FLT3 (0.56) | FLT3PIM1CCNT1MAPK8MAPK9 | |
| SCHEMBL11892641 | 0.78 | FYN (0.42) | FLT3PIM1PIM3PIM2CCNT1 | |
| SCHEMBL11892635 | 0.78 | DYRK1A (0.47) | FLT3RPS6KB1MAPK1MAPK8MAPK9 | |
| SCHEMBL10322609 | 0.74 | FLT3 (0.48) | FLT3PIM1CCNT1MAPK8MAPK9 | |
| SCHEMBL11892621 | 0.69 | PIM1 (0.40) | PIM1PIM3PIM2CCNT1MAPK1 | |
| SCHEMBL10323191 | 0.69 | MAPK8 (0.47) | FLT3PIM1PIM3PIM2RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098068-A1 | PYRAZOLO PYRIMIDINES AS DYRK1A AND DYRK1B INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |