Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.40 |
| ▸ | CDK9 | P50750 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FABP1 | P07148 | 1/20 | 0.40 |
| ▸ | FABP6 | P51161 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11892621 | 0.86 | PIM1 (0.40) | PIM1PIM3PIM2CCNT1 | |
| SCHEMBL11892636 | 0.84 | EIF2AK2 (0.41) | CCNT1CDK9CYP3A4CLK4LMNA | |
| SCHEMBL11892633 | 0.79 | FLT3 (0.42) | PIM1PIM3PIM2CCNT1CDK9 | |
| SCHEMBL11892630 | 0.79 | METAP2 (0.50) | FYNSMN1; SMN2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10353321 | 0.79 | CCNT1 (0.62) | PIM1CCNT1CDK9FLT3 | |
| SCHEMBL10323542 | 0.79 | CCNT1 (0.62) | PIM1CCNT1CDK9FLT3 | |
| SCHEMBL11892634 | 0.78 | FLT3 (0.43) | PIM1PIM3PIM2CCNT1CDK9 | |
| SCHEMBL10322654 | 0.76 | HRH3 (0.42) | CCNT1CDK9LMNAFLT3 | |
| SCHEMBL10323677 | 0.75 | LMNA (0.52) | CCNT1CDK9LMNAFLT3 | |
| SCHEMBL11321593 | 0.74 | PIM1 (0.41) | PIM1PIM3PIM2CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098068-A1 | PYRAZOLO PYRIMIDINES AS DYRK1A AND DYRK1B INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |