Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | ELANE | P08246 | 3/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | CTSG | P08311 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12491711 | 0.93 | KMT2A (0.67) | KMT2AMEN1ELANEEPHX2DDB1 | |
| SCHEMBL16835494 | 0.93 | KMT2A (0.67) | KMT2AMEN1ELANEEPHX2DDB1 | |
| SCHEMBL3189921 | 0.83 | MEN1 (0.46) | KMT2AMEN1OPRM1TSHRL3MBTL1 | |
| SCHEMBL3207582 | 0.83 | ELANE (0.56) | KMT2AMEN1ELANEEPHX2DDB1 | |
| SCHEMBL12247772 | 0.80 | KMT2A (0.54) | KMT2AMEN1ELANEEPHX2DDB1 | |
| SCHEMBL8775328 | 0.80 | KMT2A (0.54) | KMT2AMEN1ELANEEPHX2DDB1 | |
| SCHEMBL8775485 | 0.80 | KMT2A (0.54) | KMT2AMEN1ELANEEPHX2DDB1 | |
| SCHEMBL1190301 | 0.76 | KMT2A (0.50) | KMT2AMEN1ELANEEPHX2DDB1 | |
| SCHEMBL1190299 | 0.76 | KMT2A (0.50) | KMT2AMEN1ELANEEPHX2DDB1 | |
| SCHEMBL9726979 | 0.76 | KMT2A (1.00) | KMT2AMEN1ELANEEPHX2DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120058589-A | Preparation method of sitafloxacin intermediate 5-benzyl-7 (S) -tert-butylcarbonylamino-5-azaspiro [2,4] heptane | 甘肃皓天医药科技有限责任公司 | 2025-05-30 | — | — | CN | claimed |
| JP-8157455-A | — | — | None | — | — | JP | disclosed |
| JP-5221947-A | — | — | None | — | — | JP | disclosed |
| JP-11240868-A | — | — | None | — | — | JP | disclosed |
| JP-11240867-A | — | — | None | — | — | JP | disclosed |
| CN-120058589-A | Preparation method of sitafloxacin intermediate 5-benzyl-7 (S) -tert-butylcarbonylamino-5-azaspiro [2,4] heptane | 甘肃皓天医药科技有限责任公司 | 2025-05-30 | — | — | CN | disclosed |
| CN-120058589-A | Preparation method of sitafloxacin intermediate 5-benzyl-7 (S) -tert-butylcarbonylamino-5-azaspiro [2,4] heptane | 甘肃皓天医药科技有限责任公司 | 2025-05-30 | — | — | CN | disclosed |
| US-10358417-B2 | Method for preparing efficiently synthetic sitafloxacin intermediate (7S)-5-azaspiro[2.4]heptane-7-yl tert-butyl carbamate | CHEN-STONE (GUANGZHOU) CO., LTD. (CN) | 2019-07-23 | — | — | US | disclosed |
| EP-2217226-B1 | PEPTIDE DEFORMYLASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2015-07-22 | — | — | EP | disclosed |
| WO-2013177092-A1 | SUBSTITUTED ALKYNYL PYRIDINE COMPOUNDS AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2013-11-28 | — | — | WO | disclosed |
| JP-H11240868-A | 7-AMIO-5-SUBSTITUTED-5-AZASPIRO(2,4)HEPTANE DERIVATIVE | DAI ICHI SEIYAKU CO LTD | 1999-09-07 | — | — | JP | disclosed |
| JP-H11240867-A | 5-SUBSTITUTED-4,7-DIOXO-5-AZASPIRO(2,4)HEPTANE DERIVATIVE | DAI ICHI SEIYAKU CO LTD | 1999-09-07 | — | — | JP | disclosed |
| EP-0529688-B1 | Azaspiro(n,m)alkanes and diazaspiro(n,m)-alkanes | DAIICHI SEIYAKU CO (JP) | 1997-11-12 | — | — | EP | disclosed |
| JP-H08157455-A | AZASPIRO DERIVATIVE AND ITS PRODUCTION | DAI ICHI SEIYAKU CO LTD | 1996-06-18 | — | — | JP | disclosed |
| US-5508428-A | Spiro compound | DAIICHI PHAMACEUTICAL CO., LTD. (JP) | 1996-04-16 | — | — | US | disclosed |
| US-5286723-A | Spiro compound | DAIICHI SEIYAKU CO., LTD. | 1994-02-15 | — | — | US | disclosed |
| EP-0357047-B1 | Spiro compounds | DAIICHI SEIYAKU CO (JP) | 1993-11-03 | — | — | EP | disclosed |
| JP-H05221947-A | PRODUCTION OF CYCLOPROPANE DERIVATIVE | DAI ICHI SEIYAKU CO LTD | 1993-08-31 | — | — | JP | disclosed |
| EP-0529688-A2 | Azaspiro n,m alkanes and diazaspiro n,m -alkanes | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1993-03-03 | — | — | EP | disclosed |
| EP-0357047-A1 | Spiro compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-03-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10358417-B2 | Method for preparing efficiently synthetic sitafloxacin intermediate (7S)-5-azaspiro[2.4]heptane-7-yl tert-butyl carbamate | TYMS, CYP51A1, TPMT | KMT2A 2614/4885MEN1 3971/4885ELANE 2519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.