Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.65 |
| ▸ | GRM2 | Q14416 | 11/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11898152 | 1.00 | ALOX5 (0.65) | ALOX5GRM2POLBMEN1KMT2A | |
| SCHEMBL4075890 | 0.83 | ALOX5 (0.77) | ALOX5GRM2MEN1KMT2AGRM3 | |
| SCHEMBL4075891 | 0.83 | ALOX5 (0.77) | ALOX5GRM2MEN1KMT2AGRM3 | |
| SCHEMBL4079807 | 0.83 | ALOX5 (0.77) | ALOX5GRM2MEN1KMT2AGRM3 | |
| SCHEMBL11898155 | 0.82 | ALOX5 (0.70) | ALOX5GRM2POLBMEN1KMT2A | |
| SCHEMBL11898156 | 0.82 | ALOX5 (0.70) | ALOX5GRM2POLBMEN1KMT2A | |
| SCHEMBL1998244 | 0.79 | ALOX5 (0.76) | ALOX5GRM2MEN1KMT2A | |
| Setileuton SCHEMBL1528740 | 0.79 | ALOX5 (1.00) | ALOX5GRM2GRM3 | |
| Setileuton SCHEMBL29371714 | 0.79 | ALOX5 (1.00) | ALOX5GRM2GRM3 | |
| Setileuton SCHEMBL13691961 | 0.79 | ALOX5 (1.00) | ALOX5GRM2GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869031-B1 | THIADIAZOLE SUBSTITUTED COUMARIN DERIVATIVES AND THEIR USE AS LEUKOTRIENE BIOSYNTHESIS INHIBITOR | MERCK CANADA INC (CA) | 2012-08-08 | — | — | EP | claimed |