Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 11/20 | 0.34 |
| ▸ | ATXN2 | Q99700 | 5/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11901029 | 1.00 | PARP1 (0.35) | PARP1TNKSTNKS2PARP2ENPP2 | |
| SCHEMBL11962598 | 0.94 | PARP1 (0.34) | PARP1TNKSTNKS2PARP2ENPP2 | |
| SCHEMBL11962574 | 0.90 | ENPP2 (0.44) | PARP1TNKSTNKS2PARP2ENPP2 | |
| SCHEMBL1670653 | 0.89 | — | — | |
| SCHEMBL11898882 | 0.88 | ENPP2 (0.44) | PARP1TNKSTNKS2PARP2ENPP2 | |
| SCHEMBL11899245 | 0.88 | ENPP2 (0.44) | PARP1TNKSTNKS2PARP2ENPP2 | |
| SCHEMBL11962603 | 0.87 | ENPP2 (0.38) | PARP1TNKSTNKS2PARP2ENPP2 | |
| SCHEMBL11962584 | 0.86 | ENPP2 (0.41) | PARP1TNKSTNKS2PARP2ENPP2 | |
| SCHEMBL11899791 | 0.86 | ENPP2 (0.41) | PARP1TNKSTNKS2PARP2ENPP2 | |
| SCHEMBL11899790 | 0.86 | ENPP2 (0.41) | PARP1TNKSTNKS2PARP2ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552001-B2 | Sulfoxide derivatives for the treatment of tumors | MERCK PATENT GMBH (DE) | 2013-10-08 | — | — | US | disclosed |
| US-20120202827-A1 | SULFOXIDE DERIVATIVES FOR THE TREATMENT OF TUMORS | Merck Patent Gesellschaft mit beschrankter Hafung (DE) | 2012-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202827-A1 | SULFOXIDE DERIVATIVES FOR THE TREATMENT OF TUMORS | TP53, MGMT, VHL | PARP1 4339/4885TNKS 3403/4885TNKS2 3556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.