Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 4/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.37 |
| ▸ | IDH1 | O75874 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11901652 | 1.00 | CACNA1I (0.42) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL11901659 | 1.00 | CACNA1I (0.42) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL11901645 | 1.00 | CACNA1I (0.42) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL11918407 | 1.00 | CACNA1I (0.42) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL11918435 | 0.92 | CACNA1I (0.42) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL11899532 | 0.92 | CACNA1I (0.42) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL1823083 | 0.92 | CACNA1I (0.42) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL11899533 | 0.92 | CACNA1I (0.42) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL1823086 | 0.92 | CACNA1I (0.42) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL17975591 | 0.88 | CACNA1I (0.41) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493297-B1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK SHARP & DOHME (US) | 2016-08-17 | — | — | EP | disclosed |
| US-8987310-B2 | Heterocycle amide T-type calcium channel antagonists | MERCK SHARP & DOHME CORP. (US) | 2015-03-24 | — | — | US | disclosed |
| US-20120202852-A1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK SHARP & DOHME LLC | 2012-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202852-A1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | CACNA1G, CACNA1H, CACNA1I | CACNA1I 3/4885CACNA1G 1/4885CACNA1H 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.