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CACNA1G

Voltage-dependent T-type calcium channel subunit alpha-1G · O43497 · CACNA1G on Sugi Atlas →

50,582 patent compounds predicted against CACNA1G, 25,736 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL355921 SCHEMBL355921 0.52 12/20
SCHEMBL116362 SCHEMBL116362 0.45 11/20
SCHEMBL281139 SCHEMBL281139 0.47 10/20
SCHEMBL78090 SCHEMBL78090 0.58 9/20
SCHEMBL767945 SCHEMBL767945 0.50 8/20
SCHEMBL767946 SCHEMBL767946 0.50 8/20
SCHEMBL280871 SCHEMBL280871 0.46 8/20
SCHEMBL767416 SCHEMBL767416 0.40 8/20
SCHEMBL767417 SCHEMBL767417 0.40 8/20
SCHEMBL172539 SCHEMBL172539 0.54 7/20
SCHEMBL467140 SCHEMBL467140 0.48 7/20
SCHEMBL467141 SCHEMBL467141 0.48 7/20
SCHEMBL467142 SCHEMBL467142 0.48 7/20
SCHEMBL619154 SCHEMBL619154 0.41 7/20
SCHEMBL620978 SCHEMBL620978 0.40 7/20
SCHEMBL621013 SCHEMBL621013 0.40 7/20
SCHEMBL435334 SCHEMBL435334 0.55 6/20
SCHEMBL429257 SCHEMBL429257 0.50 6/20
SCHEMBL768290 SCHEMBL768290 0.50 6/20
SCHEMBL768291 SCHEMBL768291 0.50 6/20

Clinical trials — most relevant to CACNA1G by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The Effect of Pregabalin and Etoricoxib on Pain Alone Versus in Combination PHASE4UNKNOWN
Comparative Study Between Valproate and Memantine in the Prophylactic Management of Episodic Migraine. PHASE3COMPLETED
Role of Intralipid in Management of Organophosphorus Poisoning PHASE2/PHASE3WITHDRAWN
Safety and Tolerability of Lacosamide in Patients With Gain-of-function Nav1.7 Mutations Related Small Fiber Neuropathy PHASE3COMPLETED
A Phase I/II, First-In-Human Trial to Evaluate the Safety, Tolerability, and Pharmacokinetic Activity to Prevent or Treat Neuropsychiatric Symptoms in Pediatric Subjects With Timothy Syndrome PHASE1/PHASE2NOT_YET_RECRUITING
4-Aminopyridine in Episodic Ataxia Type 2 PHASE2WITHDRAWN
Safety and Efficacy of MEM 1003 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease PHASE2COMPLETED
Population Pharmacokinetic-pharmacodynamic (PK-PD) Modeling of Co-administered Gabapentin in Neuropathic Pain PHASE2COMPLETED
Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Liver Transplant Patients PHASE2WITHDRAWN
Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Trauma Patients PHASE2WITHDRAWN
Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators. PHASE2NOT_YET_RECRUITING
Physiologic Effects of Topiramate on Cognition PHASE1COMPLETED
Early Intravenous Magnesium Sulfate and Its Impact on Cerebral Vasospasm in Traumatic Subarachnoid Hemorrhage EARLY_PHASE1NOT_YET_RECRUITING
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic, Inflammatory and Takotsubo Cardiomyopathy (MEMORY) nanCOMPLETED
Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development nanRECRUITING
Role of Calcium Channels in Vascular Function nanCOMPLETED
Evaluation of A Clinical Diagnostic Test for CRDS nanRECRUITING
Sodium Channel Splicing in Heart Failure Trial (SOCS-HEFT) Prospective Study nanUNKNOWN
Sodium Channel Splicing in Heart Failure Trial nanCOMPLETED
The Use of Antiarrhythmic Drugs in Pediatrics nanUNKNOWN
Verapamil in Supraclavicular Brachial Plexus Block nanUNKNOWN
International CRDS Registry nanRECRUITING
Genetic Determinants of Sudden Cardiac Death nanCOMPLETED
Calcium Channel Splice Variant Expression in Cardiovascular Disease and Aging nanCOMPLETED
The Prevalence of RYR1-related Disease nanNOT_YET_RECRUITING
Effect of a Proposed Cav1.3 Inhibitor in Primary Aldosteronism nanCOMPLETED
Early Detection of Cardiomyopathy by Speckle Echo, High Sensitive Troponin and Cardiac Ryanodine Receptors nanUNKNOWN
MRI-phenotyping of Patients With Pathogenic Anoctamin 5 Variants nanRECRUITING
Development of an Artificial Intelligence Algorithm to Detect Pathological Repolarization Disorders on the ECG and the Risk of Ventricular Arrhythmias nanRECRUITING
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a CACNA1G binder may also engage these)

ProteinNameSimilarity
O54898 — 1.000 O54898 →
CACNA1H Voltage-dependent T-type calcium channel subunit alpha-1H 1.000 landscape →
CACNA1I Voltage-dependent T-type calcium channel subunit alpha-1I 1.000 landscape →
Q9EQ60 — 0.998 Q9EQ60 →
Q9Z0Y8 — 0.998 Q9Z0Y8 →
O88427 — 0.997 O88427 →
Q05152 — 0.996 Q05152 →
P15389 — 0.994 P15389 →
SCN5A Sodium channel protein type 5 subunit alpha 0.993 landscape →
SCN10A Sodium channel protein type 10 subunit alpha 0.993 landscape →
Q9JJV9 — 0.992 Q9JJV9 →
Q62968 — 0.992 Q62968 →
Q6QIY3 — 0.992 Q6QIY3 →
Q02343 — 0.991 Q02343 →
Q9TUI4 — 0.991 Q9TUI4 →
Q61290 — 0.991 Q61290 →
CACNA1B Voltage-dependent N-type calcium channel subunit alpha-1B 0.991 landscape →
P56698 — 0.991 P56698 →
P54282 — 0.990 P54282 →
P97445 — 0.990 P97445 →
P27732 — 0.990 P27732 →
Q07652 — 0.990 Q07652 →
Q02294 — 0.990 Q02294 →
P19024 — 0.989 P19024 →
Q61762 — 0.989 Q61762 →
O46669 — 0.989 O46669 →
Q9TTJ7 — 0.989 Q9TTJ7 →
CACNA1A Voltage-dependent P/Q-type calcium channel subunit alpha-1A 0.988 landscape →
Q9JIS7 — 0.988 Q9JIS7 →
B1AYL1 — 0.988 B1AYL1 →