Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 13/20 | 1.00 |
| ▸ | ACACA | Q13085 | 13/20 | 1.00 |
| ▸ | BACE1 | P56817 | 3/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14700725 | 1.00 | ACACB (1.00) | ACACBACACABACE1HCRTR1HCRTR2 | |
| SCHEMBL11902895 | 1.00 | ACACB (1.00) | ACACBACACABACE1HCRTR1HCRTR2 | |
| SCHEMBL14700691 | 0.93 | ACACB (0.87) | ACACBACACABACE1 | |
| SCHEMBL14689734 | 0.93 | ACACB (0.87) | ACACBACACABACE1 | |
| SCHEMBL2353464 | 0.93 | ACACB (0.87) | ACACBACACABACE1 | |
| SCHEMBL6114014 | 0.93 | ACACB (0.86) | ACACBACACABACE1 | |
| SCHEMBL6114010 | 0.93 | ACACB (0.86) | ACACBACACABACE1 | |
| SCHEMBL8280694 | 0.93 | ACACB (0.86) | ACACBACACABACE1 | |
| SCHEMBL2350374 | 0.92 | ACACB (0.84) | ACACBACACABACE1HCRTR1HCRTR2 | |
| SCHEMBL14700688 | 0.92 | ACACB (0.84) | ACACBACACABACE1HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9212140-B2 | (5s,8s)-3-(4′-chlor-3′-fluor-4-methlybiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5] dec-3-en-2-one (compound A) for treatment | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-12-15 | — | — | US | claimed |
| US-20140031407-A1 | (5S,8S)-3-(4'-CHLOR-3'-FLUOR-4-METHLYBIPHENYL-3-YL)-4-HYDROXY-8-METHOXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONE (COMPOUND A) FOR TREATMENT | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-01-30 | — | — | US | claimed |
| US-9212140-B2 | (5s,8s)-3-(4′-chlor-3′-fluor-4-methlybiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5] dec-3-en-2-one (compound A) for treatment | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-12-15 | — | — | US | disclosed |
| US-9212140-B2 | (5s,8s)-3-(4′-chlor-3′-fluor-4-methlybiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5] dec-3-en-2-one (compound A) for treatment | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-12-15 | — | — | US | disclosed |
| US-20140031407-A1 | (5S,8S)-3-(4'-CHLOR-3'-FLUOR-4-METHLYBIPHENYL-3-YL)-4-HYDROXY-8-METHOXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONE (COMPOUND A) FOR TREATMENT | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-01-30 | — | — | US | disclosed |
| US-20140031407-A1 | (5S,8S)-3-(4'-CHLOR-3'-FLUOR-4-METHLYBIPHENYL-3-YL)-4-HYDROXY-8-METHOXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONE (COMPOUND A) FOR TREATMENT | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-01-30 | — | — | US | disclosed |
| EP-2670408-A1 | (5S,8S)-3-(4'-CHLOR-3'-FLUOR-4-METHLYBIPHENYL-3-YL)-4-HYDROXY-8-METHOXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONE (COMPOUND A) FOR TREATMENT | Bayer Intellectual Property GmbH (DE) | 2013-12-11 | — | — | EP | disclosed |
| EP-2670408-A1 | (5S,8S)-3-(4'-CHLOR-3'-FLUOR-4-METHLYBIPHENYL-3-YL)-4-HYDROXY-8-METHOXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONE (COMPOUND A) FOR TREATMENT | Bayer Intellectual Property GmbH (DE) | 2013-12-11 | — | — | EP | disclosed |
| US-20130040935-A1 | CYCLIC KETO-ENOLS FOR THERAPY | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-02-14 | — | — | US | disclosed |
| WO-2012104428-A1 | (5S,8S)-3-(4'-CHLOR-3'-FLUOR-4-METHLYBIPHENYL-3-YL)-4-HYDROXY-8-METHOXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONE (COMPOUND A) FOR TREATMENT | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-08-09 | — | — | WO | disclosed |
| WO-2012104428-A1 | (5S,8S)-3-(4'-CHLOR-3'-FLUOR-4-METHLYBIPHENYL-3-YL)-4-HYDROXY-8-METHOXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONE (COMPOUND A) FOR TREATMENT | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040935-A1 | CYCLIC KETO-ENOLS FOR THERAPY | AKR1B1, AKR1C3, AKR1A1 | ACACB 310/4885ACACA 541/4885BACE1 3453/4885 |
| US-20140031407-A1 | (5S,8S)-3-(4'-CHLOR-3'-FLUOR-4-METHLYBIPHENYL-3-YL)-4-HYDROXY-8-METHOXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONE (COMPOUND A) FOR TREATMENT | AZI2, CYP8B1, VHL | ACACB 1728/4885ACACA 2009/4885BACE1 3682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.