AKR1A1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Lidorestat (SCHEMBL419032)	1.00	20/20
SCHEMBL419033	1.00	20/20
SCHEMBL419035	1.00	20/20
SCHEMBL419670	1.00	20/20
SCHEMBL419953	1.00	20/20
SCHEMBL420815	1.00	20/20
SCHEMBL420980	1.00	20/20
SCHEMBL420984	1.00	20/20
SCHEMBL420994	1.00	20/20
SCHEMBL421166	1.00	20/20
SCHEMBL442946	1.00	20/20
SCHEMBL443358	1.00	20/20
SCHEMBL443785	1.00	20/20
SCHEMBL443824	1.00	20/20
SCHEMBL443930	1.00	20/20
SCHEMBL444091	1.00	20/20
SCHEMBL444349	1.00	20/20
SCHEMBL445068	1.00	20/20
SCHEMBL445175	1.00	20/20
SCHEMBL445827	1.00	20/20

Clinical trials — most relevant to AKR1A1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Role of 5-alpha Reductase in Mediating Testosterone Actions	PHASE4	COMPLETED
Blood Pressure Regulation - Role of Potassium	PHASE4	COMPLETED
The Role of CYP8B1 Polymorphisms in Modulating the Biochemical Pathways Affected by SGLT2 Inhibitors in T2DM and Obesity	PHASE4	COMPLETED
Androgen Ablation Therapy With or Without Chemotherapy in Treating Patients With Metastatic Prostate Cancer	PHASE3	COMPLETED
Toxicity and Efficacy Evaluation of Topical Minoxidil in Acne Vulgaris	PHASE1/PHASE2	UNKNOWN
AMG 386 and Abiraterone for Advanced Prostate Cancer	PHASE2	COMPLETED
A Phase Ib/II Clinical Study of AK127 in Combination With AK112 in Patients With Advanced Solid Tumors	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
A Study of AK146D1 for Injection in Advanced Solid Tumors	PHASE1	RECRUITING
Biomarkers in Bone Marrow and Blood Samples From Patients With Prostate Cancer Treated With Ketoconazole	nan	WITHDRAWN
5-Alpha Reductase 2 as a Marker of Resistance to 5ARI Therapy	nan	RECRUITING
Tissue Predictors of Abiraterone Benefit	nan	COMPLETED
Adrenoleukodystrophy National Registry Study	nan	RECRUITING
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages	nan	COMPLETED
EndoNAFLD: Relationship Between Fatty Liver Disease and Cardiovascular Diseases	nan	COMPLETED
ALDH2 Genetic Testing in East Asian Community	nan	NOT_YET_RECRUITING
Final Height in Patients With CAH	nan	UNKNOWN
A Prospective Observational Study of Biomarkers for a Personalised IVF Treatment	nan	UNKNOWN
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Involvement of Pollutants in Atopic Dermatitis and Psoriasis	nan	UNKNOWN
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension	nan	UNKNOWN
Individualized Antiretroviral Therapy	nan	COMPLETED
Exercise Capacity, Physical Fitness, and Physical Activity Levels in Children With CAH	nan	COMPLETED
Early Mental Response - The EMRE Study	nan	RECRUITING
Gene Polymorphisms Influencing Steroid Synthesis and Action	nan	WITHDRAWN
Pharmacogenetics of Alcohol: Treatment Implications	nan	COMPLETED
Environmental and Biological Monitoring Pilot Study for Polycyclic Aromatic Hydrocarbons in Linxian, China	nan	COMPLETED
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
Tamoxifen Pharmacogenetics in Asian Breast Cancer Women	nan	UNKNOWN
Pharmacogenetic Determinants Of Treatment Response In Children	nan	RECRUITING
Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a AKR1A1 binder may also engage these)

Protein	Name	Similarity
Q5R5D5	—	1.000	Q5R5D5 →
P50578	—	1.000	P50578 →
O70473	—	1.000	O70473 →
Q28FD1	—	1.000	Q28FD1 →
Q6GMC7	—	1.000	Q6GMC7 →
Q3ZCJ2	—	0.999	Q3ZCJ2 →
Q5ZK84	—	0.999	Q5ZK84 →
P51635	—	0.998	P51635 →
Q6AZW2	—	0.998	Q6AZW2 →
P21300	—	0.997	P21300 →
P45376	—	0.996	P45376 →
Q9JII6	—	0.995	Q9JII6 →
P80276	—	0.993	P80276 →
P16116	—	0.993	P16116 →
Q9P8R5	—	0.992	Q9P8R5 →
O08782	—	0.992	O08782 →
P82125	—	0.992	P82125 →
A0A1X9QHJ0	—	0.991	A0A1X9QHJ0 →
Q9TV64	—	0.991	Q9TV64 →
Q0GYU4	—	0.991	Q0GYU4 →
Q568L5	—	0.991	Q568L5 →
Q0PGJ6	—	0.991	Q0PGJ6 →
E7C196	—	0.991	E7C196 →
AKR1D1	Aldo-keto reductase family 1 member D1	0.990	landscape →
O80944	—	0.990	O80944 →
A2Q8B5	—	0.990	A2Q8B5 →
A1D4E3	—	0.990	A1D4E3 →
B8N195	—	0.990	B8N195 →
Q5RJP0	—	0.990	Q5RJP0 →
AKR1B10	Aldo-keto reductase family 1 member B10	0.990	landscape →