Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 7/20 | 0.41 |
| ▸ | AKT1 | P31749 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | F11 | P03951 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11904825 | 1.00 | RPS6KB1 (0.41) | RPS6KB1AKT1MAPTCNR1NPSR1 | |
| SCHEMBL11904822 | 1.00 | RPS6KB1 (0.41) | RPS6KB1AKT1MAPTCNR1NPSR1 | |
| SCHEMBL2063427 | 0.90 | RPS6KB1 (0.45) | RPS6KB1AKT1 | |
| SCHEMBL2063426 | 0.90 | RPS6KB1 (0.45) | RPS6KB1AKT1 | |
| SCHEMBL11904654 | 0.90 | RPS6KB1 (0.45) | RPS6KB1AKT1 | |
| SCHEMBL11904318 | 0.89 | GPR119 (0.43) | RPS6KB1AKT1MAPTCNR1NPSR1 | |
| SCHEMBL11904015 | 0.89 | GPR119 (0.43) | RPS6KB1AKT1MAPTCNR1NPSR1 | |
| SCHEMBL2063679 | 0.82 | RPS6KB1 (0.51) | RPS6KB1AKT1MAPTCNR1NPSR1 | |
| SCHEMBL11904393 | 0.82 | GPR119 (0.45) | RPS6KB1AKT1GPR119PRMT5GRM5 | |
| SCHEMBL2063124 | 0.82 | RPS6KB1 (0.55) | RPS6KB1AKT1MAPTCNR1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358710-B1 | AKT AND P70 S6 KINASE INHIBITORS | LILLY CO ELI (US) | 2012-08-15 | — | — | EP | disclosed |