Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 20/20 | 0.62 |
| ▸ | AKT1 | P31749 | 20/20 | 0.62 |
| ▸ | AKT2 | P31751 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11904048 | 0.91 | RPS6KB1 (0.61) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL11904481 | 0.91 | RPS6KB1 (0.60) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL11904260 | 0.89 | RPS6KB1 (0.60) | RPS6KB1AKT1 | |
| SCHEMBL2063100 | 0.89 | RPS6KB1 (0.64) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL11904621 | 0.89 | RPS6KB1 (0.63) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL14782276 | 0.89 | AKT1 (0.61) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL11904398 | 0.88 | RPS6KB1 (0.65) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL11904557 | 0.88 | RPS6KB1 (0.49) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL2063212 | 0.88 | RPS6KB1 (0.49) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL2063210 | 0.88 | RPS6KB1 (0.49) | RPS6KB1AKT1AKT2KCNH2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358710-B1 | AKT AND P70 S6 KINASE INHIBITORS | LILLY CO ELI (US) | 2012-08-15 | — | — | EP | disclosed |