Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 20/20 | 0.60 |
| ▸ | AKT1 | P31749 | 20/20 | 0.60 |
| ▸ | AKT2 | P31751 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.54 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11904048 | 0.93 | RPS6KB1 (0.61) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL2063100 | 0.92 | RPS6KB1 (0.64) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL2063685 | 0.91 | RPS6KB1 (0.51) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL11904621 | 0.91 | RPS6KB1 (0.63) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL11904778 | 0.91 | RPS6KB1 (0.62) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL11904398 | 0.90 | RPS6KB1 (0.65) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL14782279 | 0.90 | RPS6KB1 (0.59) | RPS6KB1AKT1 | |
| SCHEMBL2063243 | 0.89 | RPS6KB1 (0.49) | RPS6KB1AKT1 | |
| SCHEMBL2064733 | 0.89 | RPS6KB1 (0.50) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL311278 | 0.89 | RPS6KB1 (0.59) | RPS6KB1AKT1AKT2KCNH2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970201-B1 | 6-[4-(1H-IMIDAZOL-2-YL)PIPERIDIN-1-YL]PYRIMIDIN-4-AMINE DERIVATIVES AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2019-06-19 | — | — | EP | disclosed |
| US-9867826-B2 | Heterocycles as modulators of kinase activity | MERCK PATENT GMBH (DE) | 2018-01-16 | — | — | US | disclosed |
| US-20160361316-A1 | NOVEL HETEROCYCLES AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2016-12-15 | — | — | US | disclosed |
| US-9458134-B2 | Heterocycles as modulators of kinase activity | MERCK PATENT GMBH (DE) | 2016-10-04 | — | — | US | disclosed |
| US-20160016936-A1 | NOVEL HETEROCYCLES AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2016-01-21 | — | — | US | disclosed |
| EP-2358710-B1 | AKT AND P70 S6 KINASE INHIBITORS | LILLY CO ELI (US) | 2012-08-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160361316-A1 | NOVEL HETEROCYCLES AS MODULATORS OF KINASE ACTIVITY | MAP3K20, MAP3K19, MAP3K15 | RPS6KB1 248/4885AKT1 112/4885AKT2 214/4885 |
| US-20160016936-A1 | NOVEL HETEROCYCLES AS MODULATORS OF KINASE ACTIVITY | MAP3K20, MAP3K19, MAP3K15 | RPS6KB1 248/4885AKT1 112/4885AKT2 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.