Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | OTC | P00480 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.31 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 3/20 | 0.31 |
| ▸ | NOS3 | P29474 | 2/20 | 0.31 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
| ▸ | NPY4R | P50391 | 2/20 | 0.30 |
| ▸ | NPY1R | P25929 | 1/20 | 0.30 |
| ▸ | NPY2R | P49146 | 1/20 | 0.30 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL11905875 | 0.98 | SMN1; SMN2 (0.34) | PRCPSMN1; SMN2GAARAB9AOTC | |
| Arginine SCHEMBL15110976 | 0.89 | OTC (0.39) | SMN1; SMN2GAARAB9AOTCEPHX2 | |
| Arginine SCHEMBL11905364 | 0.88 | PRCP (0.40) | PRCPSMN1; SMN2GAARAB9AOTC | |
| Arginine SCHEMBL28914483 | 0.88 | PRCP (0.40) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL17113850 | 0.88 | PRCP (0.40) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL15941091 | 0.88 | PRCP (0.40) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL20242303 | 0.88 | PRCP (0.40) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL17113848 | 0.88 | PRCP (0.40) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL1840912 | 0.88 | PRCP (0.40) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL1840910 | 0.88 | PRCP (0.40) | PRCPOTCDDAH1NOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9091700-B2 | Modified peptide substrate | MCMASTER UNIVERSITY (CA) | 2015-07-28 | — | — | US | claimed |
| US-20120208225-A1 | MODIFIED PEPTIDE SUBSTRATE | THE UNIVERSITY OF MELBOURNE (AU) | 2012-08-16 | — | — | US | claimed |
| US-10131932-B2 | Method for assaying a protease | MCMASTER UNIVERSITY | 2018-11-20 | — | — | US | disclosed |
| EP-3047033-B1 | METHOD FOR ASSAYING A PROTEASE | UNIV MCMASTER (CA) | 2018-08-22 | — | — | EP | disclosed |
| US-20160326569-A1 | METHOD FOR ASSAYING A PROTEASE | MCMASTER UNIVERSITY (CA) | 2016-11-10 | — | — | US | disclosed |
| EP-3047033-A1 | METHOD FOR ASSAYING A PROTEASE | Mcmaster University (CA) | 2016-07-27 | — | — | EP | disclosed |
| US-9091700-B2 | Modified peptide substrate | MCMASTER UNIVERSITY (CA) | 2015-07-28 | — | — | US | disclosed |
| WO-2015039211-A1 | METHOD FOR ASSAYING A PROTEASE | MCMASTER UNIVERSITY (CA) | 2015-03-26 | — | — | WO | disclosed |
| US-20120208225-A1 | MODIFIED PEPTIDE SUBSTRATE | THE UNIVERSITY OF MELBOURNE (AU) | 2012-08-16 | — | — | US | disclosed |