Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPY4R | P50391 | 3/20 | 0.35 |
| ▸ | NPY1R | P25929 | 2/20 | 0.35 |
| ▸ | NPY2R | P49146 | 2/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL11905098 | 0.98 | OTC (0.37) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL27539177 | 0.90 | OTC (0.32) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL11905345 | 0.89 | PRCP (0.35) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL11905875 | 0.89 | SMN1; SMN2 (0.34) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL244720 | 0.86 | OTC (0.43) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL8743763 | 0.83 | OTC (0.51) | OTCNOS3NOS1NOS2DDAH1 | |
| Arginine SCHEMBL31181943 | 0.82 | OTC (0.43) | OTCNOS3NOS1NOS2DDAH1 | |
| Lysine SCHEMBL237659 | 0.81 | GSR (0.54) | — | |
| Lysine SCHEMBL237658 | 0.81 | GSR (0.54) | — | |
| SCHEMBL27632265 | 0.80 | SMN1; SMN2 (0.45) | EPHX2SMN1; SMN2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013106819-A2 | ZINC-RESPONSIVE PEPTIDES, AND METHODS OF USE THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-07-18 | — | — | WO | claimed |
| US-8883962-B2 | Zinc-responsive peptides, and methods of use thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-11-11 | — | — | US | disclosed |
| US-20130224760-A1 | Zinc-Responsive Peptides, and Methods of Use Thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-08-29 | — | — | US | disclosed |
| WO-2013106819-A2 | ZINC-RESPONSIVE PEPTIDES, AND METHODS OF USE THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130224760-A1 | Zinc-Responsive Peptides, and Methods of Use Thereof | SLC30A6, SLC30A7, SLC39A3 | OTC 2148/4885NOS3 2492/4885NOS1 2881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.