Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | PRKCH | P24723 | 1/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.43 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 7/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.39 |
| ▸ | CDC42BPB | Q9Y5S2 | 3/20 | 0.39 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4468018 | 0.79 | CHKA (0.48) | ROCK2ROCK1HRH4 | |
| SCHEMBL4467284 | 0.78 | CHKA (0.47) | ROCK2ROCK1HRH4 | |
| SCHEMBL20310297 | 0.77 | CHKA (0.57) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL21341421 | 0.77 | CHKA (0.57) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL4770024 | 0.72 | MAPT (0.37) | PRKCDPIM1ROCK2ROCK1CDC42BPA | |
| SCHEMBL13178239 | 0.72 | MAP4K4 (0.51) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL30503827 | 0.72 | MAP4K4 (0.51) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL11907379 | 0.71 | PIM2 (0.53) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL11906992 | 0.71 | PIM2 (0.56) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL11908053 | 0.71 | PIM2 (0.56) | PRKCBPRKCAPRKCHPRKCEPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140249135-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2014-09-04 | — | — | US | disclosed |
| US-8822497-B2 | PIM kinase inhibitors and methods of their use | NOVARTIS AG (CH) | 2014-09-02 | — | — | US | disclosed |
| US-20120208815-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140249135-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | PIM1, PIM2, PIM3 | PRKCB 94/4885PRKCA 68/4885PRKCH 78/4885 |
| US-20120208815-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | PIM1, PIM2, PIM3 | PRKCB 94/4885PRKCA 68/4885PRKCH 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.