Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.36 |
| ▸ | PPARG | P37231 | 6/20 | 0.36 |
| ▸ | PPARD | Q03181 | 6/20 | 0.36 |
| ▸ | PPARA | Q07869 | 6/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TLR2 | O60603 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | FABP4 | P15090 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28923839 | 0.85 | CES2 (0.45) | CES2KMT2AMAPTGPR84PPARG | |
| SCHEMBL11173653 | 0.85 | CES2 (0.45) | CES2KMT2AMAPTGPR84PPARG | |
| SCHEMBL28384093 | 0.85 | CES2 (0.45) | CES2KMT2AMAPTGPR84PPARG | |
| SCHEMBL29260480 | 0.85 | CES2 (0.45) | CES2KMT2AMAPTGPR84PPARG | |
| SCHEMBL11859866 | 0.85 | CES2 (0.45) | CES2KMT2AMAPTGPR84PPARG | |
| SCHEMBL1043350 | 0.85 | CES2 (0.45) | CES2KMT2AMAPTGPR84PPARG | |
| SCHEMBL11168581 | 0.83 | CES2 (0.44) | CES2KMT2AMAPTGPR84PPARG | |
| SCHEMBL1318194 | 0.83 | CES2 (0.44) | CES2KMT2AMAPTGPR84PPARG | |
| SCHEMBL11168567 | 0.81 | CES2 (0.42) | CES2KMT2AMAPTGPR84PPARG | |
| SCHEMBL7639659 | 0.81 | CES2 (0.42) | CES2KMT2AMAPTGPR84PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221763-B2 | Process for preparing biphenyl imidazole compounds | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-12-29 | — | — | US | disclosed |
| US-20150038725-A1 | PROCESS FOR PREPARING BIPHENYL IMIDAZOLE COMPOUNDS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-02-05 | — | — | US | disclosed |
| US-20120209008-A1 | PROCESS FOR PREPARING BIPHENYL IMIDAZOLE COMPOUNDS | THERAVANCE, INC. (US) | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038725-A1 | PROCESS FOR PREPARING BIPHENYL IMIDAZOLE COMPOUNDS | CYP4F3, CYP1B1, BMI1 | CES2 3212/4885KMT2A 683/4885MAPT 2206/4885 |
| US-20120209008-A1 | PROCESS FOR PREPARING BIPHENYL IMIDAZOLE COMPOUNDS | CYP4F3, CYP1B1, BMI1 | CES2 3212/4885KMT2A 683/4885MAPT 2206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.