Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triamcinolone Acetonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 4/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 9/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 8/20 | 1.00 |
| ▸ | LMNA | P02545 | 7/20 | 1.00 |
| ▸ | PGR | P06401 | 4/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.79 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | AR | P10275 | 1/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.73 |
| ▸ | CNR1 | P21554 | 1/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.68 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triamcinolone Acetonide SCHEMBL4448 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4LMNANR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL16393966 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4LMNANR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL4002585 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4LMNANR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL12323208 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4LMNANR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL5484214 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4LMNANR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL13234864 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4LMNANR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL13839748 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4LMNANR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL11332717 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4LMNANR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL1692059 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4LMNANR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL21051778 | 1.00 | HIF1A (1.00) | HIF1ACYP3A4LMNANR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232251-B2 | Compounds for delivery of therapeutic and imaging moieties to nerve cells | MANZANITA PHARMACEUTICALS, INC. (US) | 2012-07-31 | — | — | US | disclosed |
| US-8232251-B2 | Compounds for delivery of therapeutic and imaging moieties to nerve cells | MANZANITA PHARMACEUTICALS, INC. (US) | 2012-07-31 | — | — | US | disclosed |
| US-20090286732-A1 | COMPOUNDS FOR DELIVERY OF THERAPEUTIC AND IMAGING MOIETIES TO NERVE CELLS | MANZANITA PHARMACEUTICALS, INC. | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286732-A1 | COMPOUNDS FOR DELIVERY OF THERAPEUTIC AND IMAGING MOIETIES TO NERVE CELLS | CLTB, NMBR, L1CAM | NR3C1 3019/4885HIF1A 2375/4885CYP3A4 3933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.