Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DEGS1 | O15121 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 5/20 | 0.44 |
| ▸ | RXRB | P28702 | 4/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14342568 | 1.00 | DEGS1 (0.49) | DEGS1TSHRTP53NR1H4ALDH1A1 | |
| SCHEMBL24536035 | 0.84 | DEGS1 (0.49) | DEGS1ALDH1A1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL14622010 | 0.83 | NR1H4 (0.53) | TSHRTP53NR1H4ALDH1A1SRD5A2 | |
| SCHEMBL14540155 | 0.83 | NR1H4 (0.53) | TSHRTP53NR1H4ALDH1A1SRD5A2 | |
| SCHEMBL28826290 | 0.82 | DEGS1 (0.48) | DEGS1TSHRALDH1A1HSD17B10KMT2A | |
| SCHEMBL2678109 | 0.82 | DEGS1 (0.48) | DEGS1TSHRALDH1A1HSD17B10KMT2A | |
| SCHEMBL29639824 | 0.79 | DEGS1 (0.46) | DEGS1 | |
| SCHEMBL15964829 | 0.79 | CA1 (0.50) | DEGS1TSHRALDH1A1KMT2ACA12 | |
| SCHEMBL9008920 | 0.79 | ESR1 (0.58) | TSHRTP53ALDH1A1HSD17B10SRD5A2 | |
| SCHEMBL4860270 | 0.79 | TSHR (0.52) | TSHRTP53NR1H4ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014125408-A2 | SUBSTITUTED 1H-PYRROLOPYRIDINONE DERIVATIVES AS KINASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-08-21 | — | — | WO | disclosed |
| EP-2044004-B1 | BENZAMIDE DERIVATIVES AS MODULATORS OF 11BETA-HSD1 FOR TREATING DIABETES AND OBESITY | AMGEN INC (US) | 2012-08-15 | — | — | EP | disclosed |
| EP-2029540-B1 | BENZAMIDE DERIVATIVES AND USES RELATED THERETO | AMGEN INC (US) | 2010-08-04 | — | — | EP | disclosed |
| CN-100545140-C | High-purity (fluoroalkyl) benzene derivative and preparation method thereof | MITSUBISHI GAS CHEMICAL CO (JP) | 2009-09-30 | — | — | CN | disclosed |
| WO-2007145834-A2 | BENZAMIDE DERIVATIVES AND USES RELATED THERETO | AMGEN INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| CN-1653029-A | High-purity (fluoroalkyl) benzene derivative and preparation method thereof | MITSUBISHI GAS CHEMICAL CO (JP) | 2005-08-10 | — | — | CN | disclosed |