Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13529459 | 0.83 | MEN1 (0.41) | KMT2AMEN1TGFBR1TGFBR2KDM4C | |
| SCHEMBL11920855 | 0.77 | KDM4E (0.69) | KMT2AALDH1A1MEN1KDM4EKDM4C | |
| SCHEMBL23116096 | 0.75 | MEN1 (0.44) | KMT2AMEN1TGFBR1TGFBR2KDM4C | |
| SCHEMBL7456661 | 0.75 | L3MBTL1 (0.42) | KMT2AALDH1A1POLBMEN1KDM4E | |
| SCHEMBL24553986 | 0.73 | MEN1 (0.47) | KMT2AMEN1TGFBR1TGFBR2KDM4C | |
| SCHEMBL23703927 | 0.73 | KDM4C (0.51) | KMT2AMEN1TGFBR1TGFBR2KDM4C | |
| SCHEMBL19223871 | 0.72 | MEN1 (0.41) | KMT2AALDH1A1POLBMEN1TGFBR1 | |
| SCHEMBL7460409 | 0.72 | MEN1 (0.46) | KMT2AMEN1TGFBR1TGFBR2KDM4C | |
| SCHEMBL11024894 | 0.72 | MEN1 (0.54) | KMT2AMEN1TGFBR1KDM4CNPC1 | |
| SCHEMBL15597366 | 0.72 | CA12 (0.42) | KMT2AMEN1TGFBR1KDM4CNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1438295-B1 | AZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK SERONO SA (CH) | 2012-08-15 | — | — | EP | disclosed |
| EP-2332922-A1 | N-substituted azoles and their use as MEK-1 and/or ERK-2 modulators | Merck Serono S.A. (CH) | 2011-06-15 | — | — | EP | disclosed |