Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 5/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 10/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 6/20 | 0.46 |
| ▸ | PIM1 | P11309 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11923886 | 1.00 | ALDH1A1 (0.48) | ALDH1A1HTTKDM4ENPC1TP53 | |
| SCHEMBL11923888 | 0.92 | PIM2 (0.57) | PIM2PIM3PIM1 | |
| SCHEMBL11923884 | 0.92 | PIM2 (0.57) | PIM2PIM3PIM1 | |
| SCHEMBL12831082 | 0.87 | CSF1R (0.62) | ALDH1A1HTTKDM4ENPC1TP53 | |
| SCHEMBL11924020 | 0.87 | PIM2 (0.47) | ALDH1A1HTTKDM4ENPC1TP53 | |
| SCHEMBL11924094 | 0.87 | PIM2 (0.48) | ALDH1A1HTTKDM4ENPC1TP53 | |
| SCHEMBL11924017 | 0.87 | PIM2 (0.47) | ALDH1A1HTTKDM4ENPC1TP53 | |
| SCHEMBL11924095 | 0.87 | PIM2 (0.48) | ALDH1A1HTTKDM4ENPC1TP53 | |
| SCHEMBL11924173 | 0.84 | PIM2 (0.46) | ALDH1A1HTTKDM4ENPC1TP53 | |
| SCHEMBL11924174 | 0.84 | PIM2 (0.46) | ALDH1A1HTTKDM4ENPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8669259-B2 | Heterocyclic amide compounds as protein kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-03-11 | — | — | US | disclosed |
| US-8669259-B2 | Heterocyclic amide compounds as protein kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-03-11 | — | — | US | disclosed |
| US-20120208826-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2012-08-16 | — | — | US | disclosed |
| US-20120208826-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208826-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS | CDK1, MTOR, GAK | ALDH1A1 2722/4885HTT 468/4885KDM4E 1524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.