Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11927730 | 0.90 | KIF11 (0.45) | KMT2AMEN1CREBBPHDAC1HDAC8 | |
| SCHEMBL11927728 | 0.88 | NR1H4 (0.44) | KMT2AMEN1CREBBPHDAC1HDAC8 | |
| SCHEMBL85866 | 0.88 | NR1H4 (0.44) | KMT2AMEN1CREBBPHDAC1HDAC8 | |
| SCHEMBL15176889 | 0.77 | KIF11 (0.46) | KMT2AMEN1CREBBPHDAC1HDAC8 | |
| SCHEMBL11927722 | 0.77 | NR1H4 (0.42) | KMT2ACREBBPHDAC1HDAC8HDAC6 | |
| SCHEMBL85827 | 0.76 | KIF11 (0.41) | KMT2AMEN1HDAC8HDAC6KIF11 | |
| SCHEMBL9927400 | 0.73 | KMT2A (0.61) | KMT2AMEN1CREBBPHDAC1HDAC8 | |
| SCHEMBL85722 | 0.71 | PTGS1 (0.44) | KMT2AMEN1HDAC1HDAC8HDAC6 | |
| SCHEMBL25533257 | 0.71 | PRKCI (0.60) | KMT2AMEN1CREBBPHDAC1HDAC8 | |
| SCHEMBL10198572 | 0.70 | PTGS1 (0.41) | KMT2AMEN1HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9241917-B2 | Facially amphiphilic polymers and oligomers and uses thereof | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-01-26 | — | — | US | disclosed |
| US-8236800-B2 | antimicrobial agents and antidote for hemorrhagic complications associated with heparin therapy; peptide having optimal sites of polar and nonpolar substituents that confer amphiphilic properties; leucine and aminobenzoic acid derivative; isophthalic acid and diaminobenzene, 3-tert-butyl-6-alkylthio cmpd | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-08-07 | — | — | US | disclosed |
| US-20080176807-A1 | Facially amphiphilic polymers and oligomers and uses thereof | MIDCAP FINANCIAL SBIC, LP, AS ADMINISTRATIVE AGENT | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176807-A1 | Facially amphiphilic polymers and oligomers and uses thereof | TLR3, ABHD16A, ANTXR2 | THRB 4303/4885KMT2A 4547/4885MEN1 1960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.