Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.68 |
| ▸ | GSK3B | P49841 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | BACE1 | P56817 | 3/20 | 0.58 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.56 |
| ▸ | JUN | P05412 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11928814 | 1.00 | HDAC1 (0.68) | HDAC1HDAC2HDAC8GSK3BKDM4E | |
| SCHEMBL13358184 | 0.94 | HDAC1 (0.67) | HDAC1HDAC2HDAC8GSK3BKDM4E | |
| SCHEMBL9972320 | 0.94 | HDAC1 (0.67) | HDAC1HDAC2HDAC8GSK3BKDM4E | |
| SCHEMBL13324433 | 0.92 | NFE2L2 (0.66) | HDAC1HDAC2HDAC8KDM4EALDH1A1 | |
| Dimethylcurcumin SCHEMBL3487103 | 0.89 | HDAC1 (0.78) | HDAC1HDAC2HDAC8GSK3BKDM4E | |
| Dimethylcurcumin SCHEMBL29354872 | 0.89 | HDAC1 (0.78) | HDAC1HDAC2HDAC8GSK3BKDM4E | |
| Dimethylcurcumin SCHEMBL3487105 | 0.89 | HDAC1 (0.78) | HDAC1HDAC2HDAC8GSK3BKDM4E | |
| Dimethylcurcumin SCHEMBL3686107 | 0.89 | HDAC1 (0.78) | HDAC1HDAC2HDAC8GSK3BKDM4E | |
| SCHEMBL15298306 | 0.87 | HDAC1 (0.58) | HDAC1HDAC2HDAC8GSK3BKDM4E | |
| SCHEMBL14606219 | 0.87 | NFE2L2 (0.62) | HDAC1HDAC2HDAC8KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841326-B2 | Therapeutic curcumin derivatives | STC.UNM (US) | 2014-09-23 | — | — | US | disclosed |
| US-8236852-B2 | Drugs/cosmetics having at least one (substituted phenyl)-propenal moiety; bioavailability' water solubility; antiandrogens; antiinflammatory and wound healing agents; antiarthritic agents; acne; alopecia, hirsutism; anticarcinogenic agents; cancer of the bladder, liver, breast; Kennedy's disease | ANDROSCIENCE CORPORATION (US) | 2012-08-07 | — | — | US | disclosed |
| US-20080188557-A1 | Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and use thereof | Annji Pharmaceutical Co., Ltd. (TW) | 2008-08-07 | — | — | US | disclosed |
| US-20070060644-A1 | Therapeutic curcumin derivatives | STC.UNM | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060644-A1 | Therapeutic curcumin derivatives | FABP2, GLS2, FABP1 | HDAC1 345/4885HDAC2 608/4885HDAC8 521/4885 |
| US-20080188557-A1 | Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and use thereof | AR, CYP17A1, CYP19A1 | HDAC1 59/4885HDAC2 534/4885HDAC8 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.