Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | CASP4 | P49662 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CASP9 | P55211 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5254558 | 0.85 | LMNA (0.46) | LMNANOTUMCASP1CASP3CASP4 | |
| SCHEMBL615623 | 0.81 | NOTUM (0.61) | LMNANOTUMMAPTHTTSIRT2 | |
| SCHEMBL12794666 | 0.79 | MAPT (0.42) | LMNANOTUMCASP1CASP3CASP4 | |
| SCHEMBL981641 | 0.78 | NOTUM (0.60) | LMNANOTUMALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5711977 | 0.78 | NOTUM (0.54) | LMNANOTUMNR1H2NR1H3CASP1 | |
| SCHEMBL30575716 | 0.73 | NOTUM (0.56) | LMNANOTUMALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3585115 | 0.73 | NOTUM (0.56) | LMNANOTUMALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL12794672 | 0.73 | LMNA (0.36) | LMNANOTUMCASP1CASP3CASP4 | |
| SCHEMBL2062468 | 0.73 | HTR2C (0.46) | LMNANOTUMMAPTKDM4EHTT | |
| SCHEMBL399528 | 0.72 | NOTUM (0.51) | LMNANOTUMALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257546-B1 | FUNCTIONALLY SELECTIVE ALPHA2C ADRENORECEPTOR AGONISTS | MERCK SHARP & DOHME (US) | 2012-08-15 | — | — | EP | disclosed |