Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.34 |
| ▸ | TYK2 | P29597 | 4/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14013901 | 0.84 | OPRK1 (0.36) | CDK2CCNA2CCNA1CHEK1MAPKAPK2 | |
| SCHEMBL14276368 | 0.84 | OPRK1 (0.36) | CDK2CCNA2CCNA1CHEK1MAPKAPK2 | |
| SCHEMBL11930886 | 0.83 | GSK3B (0.41) | CDK2CHEK1MAPKAPK2GSK3B | |
| SCHEMBL12953860 | 0.82 | CDK2 (0.33) | CDK2CCNA2CCNA1CHEK1MAPKAPK2 | |
| SCHEMBL12954270 | 0.82 | CDK2 (0.33) | CDK2CCNA2CCNA1CHEK1MAPKAPK2 | |
| SCHEMBL12954276 | 0.82 | TTK (0.46) | CDK2MAPKAPK2GSK3B | |
| SCHEMBL12953695 | 0.81 | GSK3B (0.44) | CDK2MAPKAPK2GSK3B | |
| SCHEMBL11930868 | 0.81 | GSK3B (0.44) | CDK2MAPKAPK2GSK3B | |
| SCHEMBL11930887 | 0.79 | GSK3B (0.38) | CDK2MAPKAPK2GSK3B | |
| SCHEMBL14412430 | 0.79 | CDK2 (0.53) | CDK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211854-B2 | Methods for inhibiting protein kinases | SCHERING CORPORATION (US) | 2012-07-03 | — | — | US | disclosed |
| US-8211854-B2 | Methods for inhibiting protein kinases | SCHERING CORPORATION (US) | 2012-07-03 | — | — | US | disclosed |
| US-20100125068-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION | 2010-05-20 | — | — | US | disclosed |
| US-20100125068-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION | 2010-05-20 | — | — | US | disclosed |
| US-20070082900-A1 | Methods for inhibiting protein kinases | SCHERING CORPORATION | 2007-04-12 | — | — | US | disclosed |
| US-20070082900-A1 | Methods for inhibiting protein kinases | SCHERING CORPORATION | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082900-A1 | Methods for inhibiting protein kinases | PIM1, AURKC, PIM3 | CDK2 64/4885CCNA2 1270/4885CCNA1 1142/4885 |
| US-20100125068-A1 | METHODS FOR INHIBITING PROTEIN KINASES | PIM1, AURKC, PIM3 | CDK2 64/4885CCNA2 1270/4885CCNA1 1142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.